PMID- 16321860
OWN - NLM
STAT- MEDLINE
DCOM- 20060620
LR  - 20190116
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 47
IP  - 2
DP  - 2006 Feb
TI  - Human leukocyte antigens in Indian patients with chronic myeloid leukemia.
PG  - 291-5
AB  - In chronic myeloid leukemia (CML), experimental studies using synthetic peptides 
      identical to the bcr-abl fusion region have revealed the capability of specific 
      peptides to bind to human leukocyte antigen (HLA) class I molecules (HLA-A2, A3, 
      A11, B8) and class II molecules (HLA-DR1, DR2, DR3, DR4 and DR11). Individuals 
      expressing HLA-A3, B8 or DR4 have a diminished risk for the development of CML in 
      Caucasian populations. A statistically significant increase in the frequency of 
      Cw3 and Cw4 antigens in Caucasians and European CML patients has been reported. 
      However, HLA associations in CML have not been reported in India. In lieu of the 
      allelic diversity of HLA in the Indian population, the present study assessed the 
      possibility of an association of HLA molecules in Indian patients with CML. HLA 
      A, B, C and DRB1 antigen associations in 180 clinically diagnosed Indian CML 
      patients (aged 17 - 54 years) were analysed and compared with age-matched (n = 
      100) healthy individuals from the same ethnic background. In the HLA class I 
      antigen distribution, a significant decrease was observed in HLA-A11 (25.6% 
      versus 39%; P = 0.027, odds ratio (OR) = 0.54, 95% confidence interval (CI) = 
      0.31 - 0.94) and HLA-Cw6 (7.8% versus 20%; P = 0.005, OR = 0.34, 95% CI = 0.15 - 
      0.74). Among the DRB1 alleles, HLA-DRB1*13 (7.8% versus 17%; P = 0.031, OR = 
      0.41, 95% CI = 0.18 - 0.93) was decreased in CML patients. However, the 
      differences for HLA-A11 (P(c) = 0.351) and DRB1*13 (P(c) = 0.403) did not remain 
      significant after the application of a correction factor for the P-value. These 
      results suggest that the development of CML is apparently associated with HLA 
      phenotypes specific to each population and indicate that expression of HLA-Cw6 
      may result in a protective effect on CML acquisition in the Indian population.
FAU - Chhaya, S U
AU  - Chhaya SU
AD  - Dhirubhai Ambani Life Sciences Centre, Molecular Diagnostics & Genetics, Rabale, 
      Navi Mumbai, 400701, India. sonalu@rediffmail.com
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Female
MH  - Gene Frequency
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - India/epidemiology
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/epidemiology/*genetics
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction/methods
EDAT- 2005/12/03 09:00
MHDA- 2006/06/21 09:00
CRDT- 2005/12/03 09:00
PHST- 2005/12/03 09:00 [pubmed]
PHST- 2006/06/21 09:00 [medline]
PHST- 2005/12/03 09:00 [entrez]
AID - L086G56784776373 [pii]
AID - 10.1080/10428190500287117 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2006 Feb;47(2):291-5. doi: 10.1080/10428190500287117.