PMID- 16322071
OWN - NLM
STAT- MEDLINE
DCOM- 20060621
LR  - 20220408
IS  - 1096-6080 (Print)
IS  - 1096-0929 (Linking)
VI  - 91
IP  - 1
DP  - 2006 May
TI  - Gallic acid inhibits histamine release and pro-inflammatory cytokine production 
      in mast cells.
PG  - 123-31
AB  - The discovery of drugs for the treatment of inflammatory allergic diseases such 
      as, asthma, allergic rhinitis, and sinusitis is a very important subject in human 
      health. Gallic acid (3,4,5-trihydroxybenzoic acid), a polyphenyl natural products 
      from gallnut and green tea, is known to have anti-oxidant, anti-inflammatory, 
      anti-microbial, and radical scavenging activities. The aim of the present study 
      was to elucidate whether gallic acid modulates the inflammatory allergic reaction 
      and to study its possible mechanisms of action. Gallic acid attenuated compound 
      48/80- or immunoglobulin E (IgE)-induced histamine release from mast cells. The 
      inhibitory effect of gallic acid on the histamine release was mediated by the 
      modulation of cAMP and intracellular calcium. Gallic acid decreased the phorbol 
      12-myristate 13-acetate plus calcium ionophore A23187-stimulated pro-inflammatory 
      cytokine gene expression and production such as TNF-alpha and IL-6 in human mast 
      cells. The inhibitory effect of gallic acid on the pro-inflammatory cytokine was 
      nuclear factor-kappaB and p38 mitogen-activated protein kinase dependent. In 
      addition, gallic acid inhibited compound 48/80-induced systemic allergic reaction 
      and IgE-mediated local allergic reaction. The inhibitory activity of gallic acid 
      on the allergic reaction and histamine release was found to be similar with 
      disodium cromoglycate. Our findings provide evidence that gallic acid inhibits 
      mast cell-derived inflammatory allergic reactions by blocking histamine release 
      and pro-inflammatory cytokine expression, and suggest the mechanisms of action. 
      Furthermore, in vivo and in vitro anti-allergic effect of gallic acid suggests a 
      possible therapeutic application of this agent in inflammatory allergic diseases.
FAU - Kim, Sang-Hyun
AU  - Kim SH
AD  - Department of Pharmacology, School of Medicine, Kyungpook National University, 
      Daegu, 700-422, Republic of Korea.
FAU - Jun, Chang-Duk
AU  - Jun CD
FAU - Suk, Kyongho
AU  - Suk K
FAU - Choi, Byung-Ju
AU  - Choi BJ
FAU - Lim, Hyunjeung
AU  - Lim H
FAU - Park, Seunja
AU  - Park S
FAU - Lee, Seung Ho
AU  - Lee SH
FAU - Shin, Hye-Young
AU  - Shin HY
FAU - Kim, Dae-Keun
AU  - Kim DK
FAU - Shin, Tae-Yong
AU  - Shin TY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051201
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
RN  - 0 (Cytokines)
RN  - 0 (DNA Primers)
RN  - 0 (Inflammation Mediators)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - 632XD903SP (Gallic Acid)
RN  - E0399OZS9N (Cyclic AMP)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Calcium/metabolism
MH  - Cyclic AMP/metabolism
MH  - Cytokines/*biosynthesis
MH  - DNA Primers
MH  - Electrophoretic Mobility Shift Assay
MH  - Enzyme Activation
MH  - Gallic Acid/*pharmacology
MH  - Histamine Release/*drug effects
MH  - Immunoglobulin E/pharmacology
MH  - Inflammation Mediators/*metabolism
MH  - Male
MH  - Mast Cells/*drug effects/metabolism
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - p-Methoxy-N-methylphenethylamine/pharmacology
MH  - p38 Mitogen-Activated Protein Kinases/metabolism
EDAT- 2005/12/03 09:00
MHDA- 2006/06/22 09:00
CRDT- 2005/12/03 09:00
PHST- 2005/12/03 09:00 [pubmed]
PHST- 2006/06/22 09:00 [medline]
PHST- 2005/12/03 09:00 [entrez]
AID - kfj063 [pii]
AID - 10.1093/toxsci/kfj063 [doi]
PST - ppublish
SO  - Toxicol Sci. 2006 May;91(1):123-31. doi: 10.1093/toxsci/kfj063. Epub 2005 Dec 1.