PMID- 16324172
OWN - NLM
STAT- MEDLINE
DCOM- 20060412
LR  - 20220408
IS  - 0017-8748 (Print)
IS  - 0017-8748 (Linking)
VI  - 45
IP  - 10
DP  - 2005 Nov-Dec
TI  - Visual cortex excitability in migraine evaluated by single and paired magnetic 
      stimuli.
PG  - 1394-9
AB  - OBJECTIVE: To determine the excitability of the visual cortex by phosphene 
      thresholds (PT) in patients with migraine using transcranial magnetic stimulation 
      (TMS) with single- and paired-pulses. METHODS: Nineteen patients with migraine 
      with aura (MWA), 19 patients with migraine without aura (MWoA), and 22 control 
      subjects were included. Patients were free from preventive anti-migraine 
      treatment and were investigated within 3 days before or after an acute migraine 
      attack. In each subject, PT were assessed by single-pulse and paired-pulse TMS 
      with an interstimulus interval of 50 ms. RESULTS: The main effect of diagnosis 
      indicated that mean PT were significantly lower in migraine patients than in 
      control subjects (P = .001). Using single-pulse TMS, mean PT tended to be lower 
      in MWoA-patients (57.7 +/- 11.8%) compared with control subjects (64.4 +/- 10.5%) 
      (P = .064). In MWA-patients, mean PT (53.1 +/- 5.7%) were significantly lower 
      compared with controls (P < .001). Using TMS with paired pulses, mean PT were 
      significantly reduced in MWoA-patients (40.3 +/- 4.9%, P = .017) as well as in 
      MWA-patients (39.6 +/- 4.2%, P = .005) compared with controls (44.6 +/- 6.0%). 
      The main effect of stimulation type indicated that mean PT were lower determined 
      with paired-pulse stimulation than with single pulses (P < .001). CONCLUSIONS: PT 
      are reduced in patients with migraine in the interictal state suggesting an 
      increased excitability of visual cortical areas. Compared with single-pulse TMS, 
      paired-pulse magnetic stimulation is more efficient to elicit phosphenes. This 
      technique provides the opportunity to evaluate visual cortex excitability with 
      lower stimulus intensities and less discomfort.
FAU - Gerwig, Marcus
AU  - Gerwig M
AD  - Department of Neurology, University of Essen, Germany.
FAU - Niehaus, Ludwig
AU  - Niehaus L
FAU - Kastrup, Oliver
AU  - Kastrup O
FAU - Stude, Philipp
AU  - Stude P
FAU - Diener, Hans C
AU  - Diener HC
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Headache
JT  - Headache
JID - 2985091R
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Migraine Disorders/*physiopathology
MH  - Phosphenes
MH  - *Transcranial Magnetic Stimulation
MH  - Visual Cortex/*physiopathology
EDAT- 2005/12/06 09:00
MHDA- 2006/04/13 09:00
CRDT- 2005/12/06 09:00
PHST- 2005/12/06 09:00 [pubmed]
PHST- 2006/04/13 09:00 [medline]
PHST- 2005/12/06 09:00 [entrez]
AID - HED272 [pii]
AID - 10.1111/j.1526-4610.2005.00272.x [doi]
PST - ppublish
SO  - Headache. 2005 Nov-Dec;45(10):1394-9. doi: 10.1111/j.1526-4610.2005.00272.x.