PMID- 16324685
OWN - NLM
STAT- MEDLINE
DCOM- 20060907
LR  - 20220310
IS  - 0006-3223 (Print)
IS  - 1873-2402 (Electronic)
IS  - 0006-3223 (Linking)
VI  - 59
IP  - 12
DP  - 2006 Jun 15
TI  - 3,4-Methylenedioxymethamphetamine in adult rats produces deficits in path 
      integration and spatial reference memory.
PG  - 1219-26
AB  - BACKGROUND: +/-3,4-Methylenedioxymethamphetamine (MDMA) is a recreational drug 
      that causes cognitive deficits in humans. A rat model for learning and memory 
      deficits has not been established, although some cognitive deficits have been 
      reported. METHODS: Male Sprague-Dawley rats were treated with MDMA (15 mg/kg x 4 
      doses) or saline (SAL) (n = 20/treatment group) and tested in different learning 
      paradigms: 1) path integration in the Cincinnati water maze (CWM), 2) spatial 
      learning in the Morris water maze (MWM), and 3) novel object recognition (NOR). 
      One week after drug administration, testing began in the CWM, then four phases of 
      MWM, and finally NOR. Following behavioral testing, monoamine levels were 
      assessed. RESULTS: +/-3,4-Methylenedioxymethamphetamine-treated rats committed 
      more CWM errors than did SAL-treated rats. 
      +/-3,4-Methylenedioxymethamphetamine-treated animals were further from the former 
      platform position during each 30-second MWM probe trial but showed no differences 
      during learning trials with the platform present. There were no group differences 
      in NOR. +/-3,4-Methylenedioxymethamphetamine depleted serotonin in all brain 
      regions and dopamine in the striatum. CONCLUSIONS: 
      +/-3,4-Methylenedioxymethamphetamine produced MWM reference memory deficits even 
      after complex learning in the CWM, where deficits in path integration learning 
      occurred. Assessment of path integration may provide a sensitive index of 
      MDMA-induced learning deficits.
FAU - Able, Jessica A
AU  - Able JA
AD  - Neuroscience Graduate Program, University of Cincinnati College of Medicine, 
      Cincinnati, Ohio, USA.
FAU - Gudelsky, Gary A
AU  - Gudelsky GA
FAU - Vorhees, Charles V
AU  - Vorhees CV
FAU - Williams, Michael T
AU  - Williams MT
LA  - eng
GR  - K01 DA014269-05/DA/NIDA NIH HHS/United States
GR  - R01 DA021394-02/DA/NIDA NIH HHS/United States
GR  - R01 DA006733-16/DA/NIDA NIH HHS/United States
GR  - R01 DA007427-16/DA/NIDA NIH HHS/United States
GR  - DA006733/DA/NIDA NIH HHS/United States
GR  - K01 DA014269/DA/NIDA NIH HHS/United States
GR  - R01 DA021394/DA/NIDA NIH HHS/United States
GR  - DA007427/DA/NIDA NIH HHS/United States
GR  - R01 DA006733/DA/NIDA NIH HHS/United States
GR  - DA014269/DA/NIDA NIH HHS/United States
GR  - R01 DA007427/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20051201
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Hallucinogens)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Cognition/drug effects
MH  - Hallucinogens/*pharmacology
MH  - Learning/*drug effects
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory Disorders/*chemically induced
MH  - Memory, Short-Term/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Recognition, Psychology/drug effects
MH  - Sodium Chloride/administration & dosage
MH  - Spatial Behavior/*drug effects
MH  - Time Factors
PMC - PMC2888296
MID - NIHMS207867
EDAT- 2005/12/06 09:00
MHDA- 2006/09/08 09:00
PMCR- 2010/06/21
CRDT- 2005/12/06 09:00
PHST- 2005/05/13 00:00 [received]
PHST- 2005/08/26 00:00 [revised]
PHST- 2005/09/12 00:00 [accepted]
PHST- 2005/12/06 09:00 [pubmed]
PHST- 2006/09/08 09:00 [medline]
PHST- 2005/12/06 09:00 [entrez]
PHST- 2010/06/21 00:00 [pmc-release]
AID - S0006-3223(05)01105-4 [pii]
AID - 10.1016/j.biopsych.2005.09.006 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2006 Jun 15;59(12):1219-26. doi: 10.1016/j.biopsych.2005.09.006. 
      Epub 2005 Dec 1.