PMID- 16324929
OWN - NLM
STAT- MEDLINE
DCOM- 20060215
LR  - 20161124
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 55
IP  - 1
DP  - 2006 Jan
TI  - Intima media thickness in childhood obesity: relations to inflammatory marker, 
      glucose metabolism, and blood pressure.
PG  - 113-8
AB  - Obesity in childhood is discussed to be associated with hypertension, 
      dyslipidemia, impaired glucose metabolism, and chronic inflammation. It has not 
      yet been studied in obese children which of these cardiovascular risk factors are 
      related to intima media thickness (IMT), a noninvasive marker for early 
      atherosclerotic changes. We collected the clinical data (age, sex, pubertal 
      stage, percentage of body fat, SD score of body mass index [SDS-BMI]) and 
      measured systolic blood pressure [SBP] and diastolic blood pressure [DBP], 
      triglycerides [TGs], high- and low-density lipoprotein cholesterol, glucose, 
      insulin, and high-sensitivity C-reactive protein [hsCRP]) in 96 obese children 
      (median age, 11 years). The control group was composed of 25 nonobese children of 
      the same age, sex, and pubertal stage. We determined the carotid IMT of all the 
      patients by B-mode ultrasound with a 14-MHz linear transducer. Obese children 
      demonstrated a significantly (P < .001) thicker intima media (median, 0.6 mm) as 
      compared with the control group (median IMT, 0.4 mm). IMT was significantly 
      correlated to the SDS-BMI (r = 0.38, P < .001), percentage of body fat (r = 0.39, 
      P < .001), SBP (r = 0.39, P < .001) and DBP (r = 0.29, P = .002), glucose (r = 
      0.30, P = .001), and hsCRP levels (r = 0.29, P = .002). In stepwise backward 
      multiple linear regression analysis, IMT correlated significantly to BMI (r2 = 
      0.05, P = .044), SBP (r2 = 0.15, P = .013), glucose (r2 = 0.05, P = .028), and 
      hsCRP (r2 = 0.07, P = .005). Because IMT is increased in obese children, vascular 
      changes in obesity seem to occur already in childhood. These changes are related 
      to the cardiovascular risk factors of obesity, especially hypertension, chronic 
      inflammation, and impaired glucose metabolism.
FAU - Reinehr, Thomas
AU  - Reinehr T
AD  - Department of Pediatrics, University of Witten/Herdecke, 45711 Datteln, Germany. 
      t.reinehr@kinderklinik-datteln.de
FAU - Kiess, Wieland
AU  - Kiess W
FAU - de Sousa, Gideon
AU  - de Sousa G
FAU - Stoffel-Wagner, Birgit
AU  - Stoffel-Wagner B
FAU - Wunsch, Ranier
AU  - Wunsch R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - 0 (Triglycerides)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adolescent
MH  - Blood Glucose/*metabolism
MH  - Blood Pressure/*physiology
MH  - Body Composition/physiology
MH  - Body Mass Index
MH  - C-Reactive Protein/metabolism
MH  - Cardiovascular Diseases/epidemiology/physiopathology
MH  - Carotid Artery, Common/diagnostic imaging/*pathology
MH  - Child
MH  - Cholesterol, HDL/blood
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - Insulin/blood
MH  - Lipids/blood
MH  - Male
MH  - Obesity/*blood/diagnostic imaging/*pathology
MH  - Puberty/physiology
MH  - Triglycerides/blood
MH  - Ultrasonography
EDAT- 2005/12/06 09:00
MHDA- 2006/02/16 09:00
CRDT- 2005/12/06 09:00
PHST- 2005/05/24 00:00 [received]
PHST- 2005/07/25 00:00 [accepted]
PHST- 2005/12/06 09:00 [pubmed]
PHST- 2006/02/16 09:00 [medline]
PHST- 2005/12/06 09:00 [entrez]
AID - S0026-0495(05)00305-7 [pii]
AID - 10.1016/j.metabol.2005.07.016 [doi]
PST - ppublish
SO  - Metabolism. 2006 Jan;55(1):113-8. doi: 10.1016/j.metabol.2005.07.016.