PMID- 16326101
OWN - NLM
STAT- MEDLINE
DCOM- 20060328
LR  - 20051226
IS  - 0960-894X (Print)
IS  - 0960-894X (Linking)
VI  - 16
IP  - 3
DP  - 2006 Feb
TI  - The design and synthesis of YC-1 analogues as probes for soluble guanylate 
      cyclase.
PG  - 618-21
AB  - Soluble guanylate cyclase (sGC) is highly activated in the presence of both YC-1 
      (1-benzyl-3-(5'-hydroxymethyl-2'-furyl)-indazole) and CO. In this report, the 
      design, synthesis, and activity (i.e., sGC activation) of photolabile analogues 
      of 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) are presented. Initial 
      results with 6-azido-3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole led to the 
      synthesis of a tritium-labeled analogue. When photoactivated, this analogue 
      labeled the alpha-subunit of sGC.
FAU - Hering, Kirk W
AU  - Hering KW
AD  - Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA.
FAU - Artz, Jennifer D
AU  - Artz JD
FAU - Pearson, William H
AU  - Pearson WH
FAU - Marletta, Michael A
AU  - Marletta MA
LA  - eng
PT  - Journal Article
DEP - 20051201
PL  - England
TA  - Bioorg Med Chem Lett
JT  - Bioorganic & medicinal chemistry letters
JID - 9107377
RN  - 0 (Enzyme Activators)
RN  - 0 (Indazoles)
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 10028-17-8 (Tritium)
RN  - 154453-18-6 (3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole)
RN  - EC 4.6.1.2 (Guanylate Cyclase)
SB  - IM
MH  - Drug Design
MH  - Enzyme Activation/drug effects
MH  - Enzyme Activators/chemistry/pharmacology
MH  - Guanylate Cyclase/*chemistry/metabolism
MH  - Indazoles/*chemical synthesis/pharmacology
MH  - Molecular Structure
MH  - Platelet Aggregation Inhibitors/chemistry/pharmacology
MH  - Solubility
MH  - Tritium/chemistry
EDAT- 2005/12/06 09:00
MHDA- 2006/03/29 09:00
CRDT- 2005/12/06 09:00
PHST- 2005/08/03 00:00 [received]
PHST- 2005/10/14 00:00 [revised]
PHST- 2005/10/14 00:00 [accepted]
PHST- 2005/12/06 09:00 [pubmed]
PHST- 2006/03/29 09:00 [medline]
PHST- 2005/12/06 09:00 [entrez]
AID - S0960-894X(05)01341-7 [pii]
AID - 10.1016/j.bmcl.2005.10.093 [doi]
PST - ppublish
SO  - Bioorg Med Chem Lett. 2006 Feb;16(3):618-21. doi: 10.1016/j.bmcl.2005.10.093. 
      Epub 2005 Dec 1.