PMID- 16327221
OWN - NLM
STAT- MEDLINE
DCOM- 20060620
LR  - 20190606
IS  - 0916-7250 (Print)
IS  - 0916-7250 (Linking)
VI  - 67
IP  - 11
DP  - 2005 Nov
TI  - Effects of androgen on plasma levels of adrenocorticotropic hormone and cortisol 
      during transportation in goats.
PG  - 1109-14
AB  - Previously, we demonstrated that plasma cortisol (Cor) levels were increased by 
      road transportation in castrated male goats, but the extent of the increase was 
      significantly reduced by 5alpha-dihydrotestosterone (DHT) implantation. This 
      study aims to clarify whether the reduction of Cor secretion by androgen during 
      transportation results from reduced plasma adrenocorticotropic hormone (ACTH). 
      Castrated goats were implanted separately with cholesterol (Cho), testosterone 
      (T) or DHT, followed by transportation. Plasma Cor levels increased during 
      transportation regardless of hormone treatment, but the levels in T and DHT 
      treated animals were lower than those in animals treated with Cho. Plasma ACTH 
      levels also increased during transportation, and those in T treated animals were 
      significantly lower than in those treated with Cho. However, plasma ACTH levels 
      in DHT treated animals varied among the animals and did not differ from those in 
      Cho treated animals. Significant and highly positive correlations between the 
      logarithm of plasma ACTH levels and plasma Cor levels were found in every 
      treatment group. The areas under the regression curves between plasma ACTH levels 
      and plasma Cor levels associated with T and DHT treatments were significantly 
      lower than those with Cho treatment. In conclusion, T was shown to reduce ACTH 
      secretion in response to transportation in castrated goats. However, this 
      suppression of the increase in Cor secretion during transportation by androgen is 
      suggested to be mainly a result of suppression of the responsiveness of the 
      adrenal cortex to ACTH.
FAU - Aoyama, Masato
AU  - Aoyama M
AD  - Faculty of Agriculture, Utsunomiya University, Japan.
FAU - Maejima, Yuko
AU  - Maejima Y
FAU - Keyaki, Satoko
AU  - Keyaki S
FAU - Muroi, Misako
AU  - Muroi M
FAU - Tohei, Atsushi
AU  - Tohei A
FAU - Sugita, Shoei
AU  - Sugita S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J Vet Med Sci
JT  - The Journal of veterinary medical science
JID - 9105360
RN  - 0 (Androgens)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adrenocorticotropic Hormone/*blood
MH  - Analysis of Variance
MH  - Androgens/administration & dosage/*pharmacology
MH  - Animals
MH  - Area Under Curve
MH  - Goats/*blood/metabolism
MH  - Hydrocortisone/*blood
MH  - Male
MH  - Orchiectomy/veterinary
MH  - Regression Analysis
MH  - *Transportation
EDAT- 2005/12/06 09:00
MHDA- 2006/06/21 09:00
CRDT- 2005/12/06 09:00
PHST- 2005/12/06 09:00 [pubmed]
PHST- 2006/06/21 09:00 [medline]
PHST- 2005/12/06 09:00 [entrez]
AID - JST.JSTAGE/jvms/67.1109 [pii]
AID - 10.1292/jvms.67.1109 [doi]
PST - ppublish
SO  - J Vet Med Sci. 2005 Nov;67(11):1109-14. doi: 10.1292/jvms.67.1109.