PMID- 16328295
OWN - NLM
STAT- MEDLINE
DCOM- 20060330
LR  - 20181113
IS  - 0014-4819 (Print)
IS  - 0014-4819 (Linking)
VI  - 168
IP  - 1-2
DP  - 2006 Jan
TI  - Long lasting attenuation by prior sounds in auditory cortex of awake primates.
PG  - 272-6
AB  - How the brain responds to sequences of sounds is a question of great relevance to 
      a variety of auditory perceptual phenomena. We investigated how long the 
      responses of neurons in the primary auditory cortex of awake monkeys are 
      influenced by the previous sound. We found that responses to the second sound of 
      a two-sound sequence were generally attenuated compared to the response that 
      sound evoked when it was presented first. The attenuation remained evident at the 
      population level even out to inter-stimulus intervals (ISIs) of 5 s, although it 
      was of modest size for ISIs >2 s. Behavioral context (performance versus 
      non-performance of a visual fixation task during sound presentation) did not 
      influence the results. The long time course of the first sound's influence 
      suggests that, under natural conditions, neural responses in auditory cortex are 
      rarely governed solely by the current sound.
FAU - Werner-Reiss, Uri
AU  - Werner-Reiss U
AD  - Department of Psychological and Brain Sciences, Center for Cognitive 
      Neuroscience, Dartmouth College, Hanover, NH 03755, USA.
FAU - Porter, Kristin Kelly
AU  - Porter KK
FAU - Underhill, Abigail M
AU  - Underhill AM
FAU - Groh, Jennifer M
AU  - Groh JM
LA  - eng
GR  - NS 17778-19/NS/NINDS NIH HHS/United States
GR  - NS 44666-02/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20051123
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
SB  - IM
MH  - Acoustic Stimulation/methods
MH  - Action Potentials/physiology
MH  - Animals
MH  - Auditory Cortex/*cytology/physiology
MH  - Auditory Perception/*physiology
MH  - Auditory Threshold/*physiology
MH  - Dose-Response Relationship, Radiation
MH  - Haplorhini
MH  - Neurons/*physiology
MH  - Reaction Time/physiology
MH  - Time Factors
MH  - *Wakefulness
EDAT- 2005/12/06 09:00
MHDA- 2006/03/31 09:00
CRDT- 2005/12/06 09:00
PHST- 2005/02/16 00:00 [received]
PHST- 2005/10/05 00:00 [accepted]
PHST- 2005/12/06 09:00 [pubmed]
PHST- 2006/03/31 09:00 [medline]
PHST- 2005/12/06 09:00 [entrez]
AID - 10.1007/s00221-005-0184-x [doi]
PST - ppublish
SO  - Exp Brain Res. 2006 Jan;168(1-2):272-6. doi: 10.1007/s00221-005-0184-x. Epub 2005 
      Nov 23.