PMID- 16328928
OWN - NLM
STAT- MEDLINE
DCOM- 20060711
LR  - 20181113
IS  - 0012-4486 (Print)
IS  - 0012-4486 (Linking)
VI  - 110
IP  - 2-3
DP  - 2005 Mar-May
TI  - Pattern VEP alterations in psoriatic patients may indicate a sub clinic optic 
      neuritis.
PG  - 203-7
AB  - We examined 44 subject (Group A) of both sexes (27 males and 17 females) aging 
      between 16 and 80 (average: 45+/-16.6), divided into age bands, affected by 
      mild-medium psoriasis with PASI (psoriasis area and severity index) between 1.2 
      and 48.6 (average: 11.2+/-9.7) without any other disease and we performed pattern 
      transient VEP (Visual Evoked Potential) at the frequencies usually used in 
      clinical experience (73', 36', 18' check size). For a good statistic comparison 
      we choose 55 healthy subjects (group B) divided into age bands on which we 
      performed the same test. Comparison of VEP parameters between psoriatic and 
      healthy subjects, showed in group A 10 normal (22.7%) and 34 pathological 
      (77.3%). In the latter group there are 16 subjects who show only a P100 reduced 
      amplitude (36.3%), 3 with only increased latency (6.8%), 15 with alterations of 
      both values (34%). The achieved data show that more than 3/4 of group A subjects 
      have VEP alterations as index of the presence of a sub clinic optic neuritis with 
      a probably toxic autoimmune origin due to the action of TNFalpha, of IgG, of ECP 
      or of other cytokines (IL6, IL7, etc) that are increased in the blood of this 
      patients. The electro physiologic monitoring of optic nerve seems to represent a 
      good routine test to evaluate the global conditions of psoriatic patients.
FAU - Perossini, M
AU  - Perossini M
AD  - Clinica Oculistica, Universita di Pisa, Italy. mpeross@tin.it
FAU - Turio, E
AU  - Turio E
FAU - Perossini, T
AU  - Perossini T
FAU - Romagnoli, M
AU  - Romagnoli M
FAU - Benedetti, S
AU  - Benedetti S
FAU - Cei, G
AU  - Cei G
FAU - Barachini, P
AU  - Barachini P
FAU - Nardi, M
AU  - Nardi M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Doc Ophthalmol
JT  - Documenta ophthalmologica. Advances in ophthalmology
JID - 0370667
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Evoked Potentials, Visual/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Optic Neuritis/etiology/*physiopathology
MH  - Prognosis
MH  - Psoriasis/*complications/physiopathology
MH  - Severity of Illness Index
EDAT- 2005/12/06 09:00
MHDA- 2006/07/13 09:00
CRDT- 2005/12/06 09:00
PHST- 2005/03/28 00:00 [accepted]
PHST- 2005/12/06 09:00 [pubmed]
PHST- 2006/07/13 09:00 [medline]
PHST- 2005/12/06 09:00 [entrez]
AID - 10.1007/s10633-005-4830-1 [doi]
PST - ppublish
SO  - Doc Ophthalmol. 2005 Mar-May;110(2-3):203-7. doi: 10.1007/s10633-005-4830-1.