PMID- 16329058
OWN - NLM
STAT- MEDLINE
DCOM- 20060131
LR  - 20190917
IS  - 1120-6721 (Print)
IS  - 1120-6721 (Linking)
VI  - 15
IP  - 6
DP  - 2005 Nov-Dec
TI  - Conventional perimetry, short-wavelength automated perimetry, frequency-doubling 
      technology, and visual evoked potentials in the assessment of patients with 
      multiple sclerosis.
PG  - 730-8
AB  - PURPOSE: To evaluate the diagnostic power of conventional, achromatic, automated 
      perimetry (CAP), short-wavelength automated perimetry (SWAP), frequency-doubling 
      technology (FDT) perimetry, and visual evoked potentials (VEP) in a group of 
      patients with multiple sclerosis (MS) with or without a history of optic 
      neuritis. METHODS: Thirty eyes of 15 patients (5 male, 10 female, average age 
      38+/-7 years) with confirmed diagnosis of MS underwent CAP, SWAP (Humphrey 750-II 
      VFA, program central 30-2, full-threshold strategy), FDT perimetry (program 
      N-30), and pattern VEPs. Sixteen eyes (53.3%) had no history of ocular 
      involvement and a negative ophthalmologic examination. They were matched with a 
      control group of 10 healthy volunteers (4 male, 6 female, average age 31+/-10 
      years). The mean deviation (MD) and the pattern standard deviation (PSD) of the 
      two groups were compared (t-test). Fourteen eyes (46.7%) had, on the contrary, a 
      history of optic neuritis. Inside this group, the MD and the PSD of the three 
      techniques were correlated (Spearman's rank test), in order to investigate 
      whether any significant differences might be revealed by these techniques in 
      pointing out the total amount of visual field damage. RESULTS: When comparing MS 
      patients without signs or symptoms of ocular involvement and a control group, no 
      significant differences were found for CAP MD, CAP PSD, and FDT PSD. Significant 
      differences were found, on the contrary, for SWAP MD (p=0.0014), SWAP PSD 
      (p=0.0001), and FDT MD (p=0.0001). When considering the MD and the PSD of the 
      three techniques in the group of MS patients who had a history of optic neuritis, 
      a significant correlation was found only between CAP MD and SWAP MD (r=0.0057), 
      with a tendency by SWAP to reveal a higher rate of visual field loss. The other 
      correlations were not significant. According to predefined criteria, the group of 
      asymptomatic subjects had abnormal CAP in 1 eye (6.25%), abnormal SWAP in 9 
      (56.2%), abnormal FDT in 11 (68.7%), and abnormal VEPs in 7 (43.7%). The combined 
      use of all techniques allowed us to identify silent optic nerve impairment in 15 
      (93.7%) eyes. CONCLUSIONS: Short-wavelength automated perimetry and FDT perimetry 
      are two non-conventional perimetric techniques that were mainly developed for the 
      early detection of glaucomatous damage. The results of this study demonstrate 
      their efficacy also in detecting early visual field deficits in MS patients 
      without clinical signs of optic neuropathy. Frequency doubling perimetry, in 
      particular, proved to be an easy, fast, and sensitive technique in the assessment 
      of patients with MS. Our results also suggest that subclinical visual involvement 
      in MS can be better diagnosed using multiple (neurophysiologic and 
      psychophysical) tests.
FAU - Corallo, G
AU  - Corallo G
AD  - Eye Clinic, Dept. of Neurosciences, Ophthalmology and Genetics, University of 
      Genova, Genova, Italy. Guido.Corallo@unige.it
FAU - Cicinelli, S
AU  - Cicinelli S
FAU - Papadia, M
AU  - Papadia M
FAU - Bandini, F
AU  - Bandini F
FAU - Uccelli, A
AU  - Uccelli A
FAU - Calabria, G
AU  - Calabria G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
SB  - IM
MH  - Adult
MH  - *Evoked Potentials, Visual
MH  - Female
MH  - Humans
MH  - Male
MH  - Multiple Sclerosis/*diagnosis
MH  - Optic Neuritis/*diagnosis
MH  - Sensitivity and Specificity
MH  - Vision Disorders/*diagnosis
MH  - Visual Field Tests/*methods
MH  - *Visual Fields
EDAT- 2005/12/06 09:00
MHDA- 2006/02/01 09:00
CRDT- 2005/12/06 09:00
PHST- 2005/12/06 09:00 [pubmed]
PHST- 2006/02/01 09:00 [medline]
PHST- 2005/12/06 09:00 [entrez]
AID - 10.1177/112067210501500612 [doi]
PST - ppublish
SO  - Eur J Ophthalmol. 2005 Nov-Dec;15(6):730-8. doi: 10.1177/112067210501500612.