PMID- 16329133
OWN - NLM
STAT- MEDLINE
DCOM- 20060310
LR  - 20181203
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 106
IP  - 1
DP  - 2006 Jan 1
TI  - Co-overexpression of fibroblast growth factor 3 and epidermal growth factor 
      receptor is correlated with the development of nonsmall cell lung carcinoma.
PG  - 146-55
AB  - BACKGROUND: Lung cancer is a prevalent cancer with a poor prognosis. To develop a 
      useful in vitro cell model, a cell line of lung squamous cell carcinoma (SCC-35) 
      was established. METHODS: The SCC-35 cell was characterized by comparative 
      genomic hybridization (CGH) and spectral karyotyping (SKY). Chromosome 
      microdissection, fluorescence in situ hybridization (FISH), and Southern and 
      Northern blots analyses were used to study target genes. RESULTS: Two amplicons 
      were found at chromosomes 7p12 and 11q13. Amplification and overexpression of 
      epidermal growth factor receptor (EGFR) at 7p12 and fibroblast growth factor 3 
      (FGF3) at 11q13 were found. To understand the correlation between these two genes 
      in nonsmall cell lung carcinoma (NSCLC) more comprehensively, overexpression of 
      FGF3 and EGFR was investigated by immunohistochemistry with a tissue microarray 
      containing 406 NSCLC samples. Cytoplasmic overexpression of FGF3 and EGFR was 
      detected in 61% and 69% NSCLC cases, respectively. More interestingly, a 
      significant correlation between overexpression of FGF3 and EGFR was found in 
      NSCLC. CONCLUSION: These results suggest that co-overexpression of FGF3 and EGFR 
      may play an important role in the pathogenesis of lung carcinoma.
CI  - Copyright 2005 American Cancer Society.
FAU - Tai, Amy L S
AU  - Tai AL
AD  - Department of Clinical Oncology, the University of Hong Kong, Hong Kong, China.
FAU - Sham, Jonathan S T
AU  - Sham JS
FAU - Xie, Dan
AU  - Xie D
FAU - Fang, Yan
AU  - Fang Y
FAU - Wu, Yi-Long
AU  - Wu YL
FAU - Hu, Liang
AU  - Hu L
FAU - Deng, Wen
AU  - Deng W
FAU - Tsao, George S W
AU  - Tsao GS
FAU - Qiao, Gui-Bin
AU  - Qiao GB
FAU - Cheung, Annie L M
AU  - Cheung AL
FAU - Guan, Xin-Yuan
AU  - Guan XY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 0 (FGF3 protein, human)
RN  - 0 (Fibroblast Growth Factor 3)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 2.7.7.49 (Telomerase)
SB  - IM
MH  - Carcinoma, Non-Small-Cell Lung/genetics/*metabolism
MH  - Carcinoma, Squamous Cell/genetics/*metabolism
MH  - Cell Line, Tumor
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Chromosomes, Human, Pair 7/genetics
MH  - ErbB Receptors/genetics/*metabolism
MH  - Fibroblast Growth Factor 3/genetics/*metabolism
MH  - Humans
MH  - Lung Neoplasms/genetics/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Spectral Karyotyping
MH  - Telomerase/genetics/metabolism
MH  - Tissue Array Analysis
EDAT- 2005/12/06 09:00
MHDA- 2006/03/11 09:00
CRDT- 2005/12/06 09:00
PHST- 2005/12/06 09:00 [pubmed]
PHST- 2006/03/11 09:00 [medline]
PHST- 2005/12/06 09:00 [entrez]
AID - 10.1002/cncr.21581 [doi]
PST - ppublish
SO  - Cancer. 2006 Jan 1;106(1):146-55. doi: 10.1002/cncr.21581.