PMID- 16330001
OWN - NLM
STAT- MEDLINE
DCOM- 20060215
LR  - 20161124
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1066
IP  - 1-2
DP  - 2005 Dec 20
TI  - Effects of sexual experience on conspecific odor preference and estrous 
      odor-induced activation of the vomeronasal projection pathway and the nucleus 
      accumbens in male rats.
PG  - 101-8
AB  - Male rats prefer odors from estrous females to those from sexually active males. 
      Several studies, however, have demonstrated that prior sexual experience was 
      required to develop the preference for estrous odor. Immunohistological methods 
      for visualizing Fos protein have been shown that in sexually experienced male 
      rats, estrous odors activate brain areas throughout the vomeronasal projection 
      pathway (VN pathway) and the nucleus accumbens (NAcc). In the present study, we 
      examined the contribution of prior sexual experience to the estrous odor-induced 
      neuronal activation of these brain areas in relation to the development of the 
      preference for estrous odor. Sexually experienced testosterone-implanted 
      castrates showed the preference for the odor from an estrous female as opposed to 
      the odor from a sexually active male. In these subjects, significant increment of 
      Fos-like immunoreactivity (Fos-Li) after exposure to estrous female soiled 
      bedding was observed in all brain regions examined, confirming the results of 
      previous studies. Sexually naive subjects, on the other hand, did not show the 
      preference for estrous odor and the significant increment of Fos-Li was observed 
      only in the accessory olfactory bulb (AOB) and the posterior-dorsal medial 
      amygdala (MePD) of the VN pathway. These results suggested that sexual experience 
      is required for the estrous odor-induced activation of more central portions of 
      the VN pathway, such as the medial preoptic area (mPOA) and the bed nucleus of 
      the stria terminalis (BNST), and the NAcc. The activation of some of these brain 
      regions, therefore, is probably involved in the development of the preference for 
      estrous odor.
FAU - Hosokawa, Nami
AU  - Hosokawa N
AD  - Life Science Insititute, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo 
      102-8554, Japan.
FAU - Chiba, Atsuhiko
AU  - Chiba A
LA  - eng
PT  - Journal Article
DEP - 20051205
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Drug Implants)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Amygdala/physiology
MH  - Animals
MH  - Drug Implants
MH  - Estrous Cycle/*physiology
MH  - Female
MH  - Genes, fos/genetics
MH  - Immunohistochemistry
MH  - Male
MH  - Nucleus Accumbens/*physiology
MH  - *Odorants
MH  - Olfactory Pathways/*physiology
MH  - Orchiectomy
MH  - Preoptic Area/physiology
MH  - Rats
MH  - Rats, Long-Evans
MH  - *Sexual Behavior, Animal
MH  - Testosterone/administration & dosage/pharmacology
MH  - Vomeronasal Organ/*physiology
EDAT- 2005/12/07 09:00
MHDA- 2006/02/16 09:00
CRDT- 2005/12/07 09:00
PHST- 2005/06/10 00:00 [received]
PHST- 2005/10/12 00:00 [revised]
PHST- 2005/10/15 00:00 [accepted]
PHST- 2005/12/07 09:00 [pubmed]
PHST- 2006/02/16 09:00 [medline]
PHST- 2005/12/07 09:00 [entrez]
AID - S0006-8993(05)01474-5 [pii]
AID - 10.1016/j.brainres.2005.10.036 [doi]
PST - ppublish
SO  - Brain Res. 2005 Dec 20;1066(1-2):101-8. doi: 10.1016/j.brainres.2005.10.036. Epub 
      2005 Dec 5.