PMID- 16330359
OWN - NLM
STAT- MEDLINE
DCOM- 20060721
LR  - 20181113
IS  - 0091-6765 (Print)
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Linking)
VI  - 113
IP  - 12
DP  - 2005 Dec
TI  - Aryl hydrocarbon receptor-independent toxicity of weathered crude oil during fish 
      development.
PG  - 1755-62
AB  - Polycyclic aromatic hydrocarbons (PAHs), derived largely from fossil fuels and 
      their combustion, are pervasive contaminants in rivers, lakes, and nearshore 
      marine habitats. Studies after the Exxon Valdez oil spill demonstrated that fish 
      embryos exposed to low levels of PAHs in weathered crude oil develop a syndrome 
      of edema and craniofacial and body axis defects. Although mechanisms leading to 
      these defects are poorly understood, it is widely held that PAH toxicity is 
      linked to aryl hydrocarbon receptor (AhR) binding and cytochrome P450 1A (CYP1A) 
      induction. Using zebrafish embryos, we show that the weathered crude oil syndrome 
      is distinct from the well-characterized AhR-dependent effects of dioxin toxicity. 
      Blockade of AhR pathway components with antisense morpholino oligonucleotides 
      demonstrated that the key developmental defects induced by weathered crude oil 
      exposure are mediated by low-molecular-weight tricyclic PAHs through 
      AhR-independent disruption of cardiovascular function and morphogenesis. These 
      findings have multiple implications for the assessment of PAH impacts on coastal 
      habitats.
FAU - Incardona, John P
AU  - Incardona JP
AD  - Ecotoxicology and Environmental Fish Health Program, Environmental Conservation 
      Division, Northwest Fisheries Science Center, National Oceanic and Atmospheric 
      Administration, Seattle, Washington 98112, USA. john.incardona@noaa.gov
FAU - Carls, Mark G
AU  - Carls MG
FAU - Teraoka, Hiroki
AU  - Teraoka H
FAU - Sloan, Catherine A
AU  - Sloan CA
FAU - Collier, Tracy K
AU  - Collier TK
FAU - Scholz, Nathaniel L
AU  - Scholz NL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Oligonucleotides)
RN  - 0 (Petroleum)
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - 0 (Receptors, Aryl Hydrocarbon)
SB  - IM
MH  - Abnormalities, Multiple/chemically induced/*veterinary
MH  - Animals
MH  - Body Patterning/drug effects
MH  - Cardiovascular System/drug effects
MH  - Embryo, Nonmammalian/drug effects
MH  - Fish Diseases/*chemically induced/*embryology
MH  - Microscopy, Fluorescence/veterinary
MH  - Oligonucleotides
MH  - Petroleum/analysis/*toxicity
MH  - Polycyclic Aromatic Hydrocarbons/analysis/*toxicity
MH  - Receptors, Aryl Hydrocarbon/genetics/metabolism
MH  - *Zebrafish
PMC - PMC1315066
EDAT- 2005/12/07 09:00
MHDA- 2006/07/22 09:00
PMCR- 2005/12/01
CRDT- 2005/12/07 09:00
PHST- 2005/12/07 09:00 [pubmed]
PHST- 2006/07/22 09:00 [medline]
PHST- 2005/12/07 09:00 [entrez]
PHST- 2005/12/01 00:00 [pmc-release]
AID - ehp0113-001755 [pii]
AID - 10.1289/ehp.8230 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2005 Dec;113(12):1755-62. doi: 10.1289/ehp.8230.