PMID- 16331314
OWN - NLM
STAT- MEDLINE
DCOM- 20060420
LR  - 20180525
IS  - 1198-2241 (Print)
IS  - 1198-2241 (Linking)
VI  - 12
IP  - 8
DP  - 2005 Nov-Dec
TI  - Total and specific immunoglobulin E and their relationship to respiratory 
      symptoms in Quebec children and adolescents.
PG  - 426-32
AB  - BACKGROUND: Respiratory disease is a major cause of morbidity in young people. It 
      is now recognized that atopy plays an important role in the development of 
      chronic respiratory symptoms in children. OBJECTIVE: To examine the determinants 
      and consequences of serum total and specific immunoglobulin E (IgE) in a general 
      population sample of Quebec children and adolescents. METHODS: In 1999, 2349 
      children and adolescents (nine, 13 or 16 years of age) who had participated in a 
      respiratory symptom and disease questionnaire had their total IgE measured. Of 
      these participants, a subsample of 451 children and adolescents was analyzed to 
      detect antibodies to eight specific allergens (ie, allergens of dust mites 
      [Dermatophagoides farinae and Dermatophagoides pteronyssinus], cat, dog, ragweed, 
      Timothy grass, mould [alternaria] and cockroach). RESULTS: The geometric mean of 
      the total IgE was 44.4 U/mL among all participants. Concentrations were higher in 
      boys and increased with age. More than 41% of the participants were sensitized to 
      at least one specific allergen. Such sensitization was strongly associated with 
      the occurrence of respiratory conditions and symptoms, namely asthma, wheezing 
      and rhinitis. Family history, school location and ethnic origin had an impact on 
      the prevalence of atopy and total IgE levels. CONCLUSIONS: Allergic sensitization 
      is a major determinant in the development of asthma, wheezing and rhinitis in 
      children and adolescents in the province of Quebec.
FAU - Levesque, Benoit
AU  - Levesque B
AD  - CHUL Centre de recherche du CHUQ, Sainte-Foy, Canada. Benoit.Levesque@inspq.qc.ca
FAU - Duchesne, Jean-Francois
AU  - Duchesne JF
FAU - Gingras, Suzanne
AU  - Gingras S
FAU - Allard, Pierre
AU  - Allard P
FAU - Delvin, Edgar
AU  - Delvin E
FAU - Aubin, Jacinthe
AU  - Aubin J
FAU - Rhainds, Marc
AU  - Rhainds M
FAU - Lajoie, Pierre
AU  - Lajoie P
FAU - Ernst, Pierre
AU  - Ernst P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Egypt
TA  - Can Respir J
JT  - Canadian respiratory journal
JID - 9433332
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/immunology
MH  - Animals
MH  - Chi-Square Distribution
MH  - Child
MH  - Female
MH  - Humans
MH  - Hypersensitivity/immunology
MH  - Immunoglobulin E/*blood
MH  - Logistic Models
MH  - Male
MH  - Quebec
MH  - Respiratory Tract Diseases/*immunology
EDAT- 2005/12/07 09:00
MHDA- 2006/04/21 09:00
CRDT- 2005/12/07 09:00
PHST- 2005/12/07 09:00 [pubmed]
PHST- 2006/04/21 09:00 [medline]
PHST- 2005/12/07 09:00 [entrez]
AID - 10.1155/2005/248714 [doi]
PST - ppublish
SO  - Can Respir J. 2005 Nov-Dec;12(8):426-32. doi: 10.1155/2005/248714.