PMID- 16333831
OWN - NLM
STAT- MEDLINE
DCOM- 20061213
LR  - 20090112
IS  - 1545-5009 (Print)
IS  - 1545-5009 (Linking)
VI  - 47
IP  - 5
DP  - 2006 Oct 15
TI  - Human herpesvirus 6 infection and transient acquired myelodysplasia in children.
PG  - 543-8
AB  - BACKGROUND: To demonstrate that primary human herpesvirus 6 (HHV-6) infection in 
      childhood can cause hematopoietic dysplasia that mimics a myelodysplastic 
      syndrome (MDS) in severe cases. PROCEDURE: Seven immunocompetent children, who 
      presented at admission with concomitant cytopenias in blood and morphologic 
      features of dysplasia in bone marrow, were evaluated. Diagnosis of acute HHV-6 
      infection was secondary made by detection of HHV-6 DNA in plasma, bone marrow, or 
      cerebrospinal fluid and measurement of plasma antibody titers. Peripheral blood 
      and bone marrow aspirate smears were examined at diagnosis and during follow-up. 
      Morphologic recognition of myelodysplasia was made according to the 
      recommendations of the Third MIC Cooperative Group. RESULTS: Anemia was the most 
      frequent cytopenia (five of seven cases). Bi- or tri-lineage dysplasia was 
      observed in the marrow samples. Granulocytic and erythroid cells were always 
      affected with dysgranulopoiesis and dyserythropoiesis scores equal to or higher 
      than 3. Myelodysplasia was not due to a clonal disorder and disappeared gradually 
      within 1 or 2 months. CONCLUSIONS: Our results indicate that severe HHV-6 
      infection may induce reversible myelodysplastic changes. These findings 
      contribute to elucidate the pathogenicity of HHV-6 and furthermore suggest that 
      HHV-6 infection must also be considered as a cause of dysplasia in the 
      differential diagnosis of MDS.
CI  - Copyright (c) 2005 Wiley-Liss, Inc.
FAU - Kagialis-Girard, Sandrine
AU  - Kagialis-Girard S
AD  - Hematology Laboratory, Hopital Debrousse, Hospices Civils de Lyon, and Hematology 
      Laboratory, Faculty of Pharmacy, Claude Bernard University, Lyon, France. 
      sandrine.girard@chu-lyon.fr
FAU - Durand, Brigitte
AU  - Durand B
FAU - Mialou, Valerie
AU  - Mialou V
FAU - Pages, Marie-Pierre
AU  - Pages MP
FAU - Galambrun, Claire
AU  - Galambrun C
FAU - Bertrand, Yves
AU  - Bertrand Y
FAU - Negrier, Claude
AU  - Negrier C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatr Blood Cancer
JT  - Pediatric blood & cancer
JID - 101186624
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Blood Cell Count
MH  - Bone Marrow/pathology
MH  - Child, Preschool
MH  - Comorbidity
MH  - Convalescence
MH  - Diagnosis, Differential
MH  - Female
MH  - Follow-Up Studies
MH  - France/epidemiology
MH  - Herpesvirus 6, Human/isolation & purification
MH  - Humans
MH  - Infant
MH  - Male
MH  - Myelodysplastic Syndromes/*diagnosis/epidemiology/therapy
MH  - Retrospective Studies
MH  - Roseolovirus Infections/*diagnosis/epidemiology/therapy
MH  - Treatment Outcome
EDAT- 2005/12/08 09:00
MHDA- 2006/12/14 09:00
CRDT- 2005/12/08 09:00
PHST- 2005/12/08 09:00 [pubmed]
PHST- 2006/12/14 09:00 [medline]
PHST- 2005/12/08 09:00 [entrez]
AID - 10.1002/pbc.20667 [doi]
PST - ppublish
SO  - Pediatr Blood Cancer. 2006 Oct 15;47(5):543-8. doi: 10.1002/pbc.20667.