PMID- 16334298
OWN - NLM
STAT- MEDLINE
DCOM- 20060712
LR  - 20170203
IS  - 0254-8704 (Print)
IS  - 0254-8704 (Linking)
VI  - 26
IP  - 3
DP  - 2005 Jul
TI  - Metabolic dysregulation and inhibition of spermatogenesis by gibberellic acid in 
      rat testicular cells.
PG  - 567-9
AB  - Enzymatic and histological change in the testicular cells of rats treated orally 
      and intradermally for 45 days with gibberellic acid (GBA) in independent studies 
      is reported. Assay of hexokinase (HK), acid phosphatase (AcP) and alkaline 
      phosphatase (AkP) in rat testicular tissue homogenate preparations yielded 
      results that suggested changes in these enzyme activities relative to their 
      respective controls. Histological studies showed loss of germ cells, derangement 
      of the germinal cells, and reduction in the size of the seminiferous tubules and 
      dystrophy of Leydig cells. More importantly decreased sperm count in the lumen 
      was observed. A dysregulatory role is thus established for GBA in rat testicular 
      cell function. This compound may serve as an inhibitor of testicular cell 
      function.
FAU - Ravikumar, S
AU  - Ravikumar S
AD  - Department of Biological Sciences, Pondicherry University, India.
FAU - Srikumar, K
AU  - Srikumar K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - India
TA  - J Environ Biol
JT  - Journal of environmental biology
JID - 8300544
RN  - 0 (Gibberellins)
RN  - 0 (Tissue Extracts)
RN  - BU0A7MWB6L (gibberellic acid)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 3.1.3.1 (Alkaline Phosphatase)
RN  - EC 3.1.3.2 (Acid Phosphatase)
SB  - IM
MH  - Acid Phosphatase/metabolism
MH  - Alkaline Phosphatase/metabolism
MH  - Animals
MH  - Gibberellins/*toxicity
MH  - Hexokinase/metabolism
MH  - Male
MH  - Rats
MH  - Spermatogenesis/*drug effects
MH  - Testis/*cytology/drug effects/*enzymology/physiology
MH  - Tissue Extracts/*metabolism
EDAT- 2005/12/13 09:00
MHDA- 2006/07/13 09:00
CRDT- 2005/12/13 09:00
PHST- 2005/12/13 09:00 [pubmed]
PHST- 2006/07/13 09:00 [medline]
PHST- 2005/12/13 09:00 [entrez]
PST - ppublish
SO  - J Environ Biol. 2005 Jul;26(3):567-9.