PMID- 16334979
OWN - NLM
STAT- MEDLINE
DCOM- 20060111
LR  - 20071115
IS  - 1233-9687 (Print)
IS  - 1233-9687 (Linking)
VI  - 56
IP  - 3
DP  - 2005
TI  - CC chemokines and chemokine receptors in IgA nephropathy (IgAN) and in non-IgA 
      mesangial proliferative glomerulonephritis (MesProGN). the immunohistochemical 
      comparative study.
PG  - 121-6
AB  - The aim of the study was to compare the immunoexpression of monocyte 
      chemoattractant protein-1 (MCP-1), monocyte inflammatory protein-1alpha 
      (MIP-1alpha), Regulated upon Activation Normal T-cell Expressed and Secreted 
      (RANTES) and CC chemokine receptors: CCR1 and CCR5 in renal biopsy specimens in 
      IgA nephropathy (IgAN) and in non-IgA mesangial proliferative glomerulonephritis 
      (MesProGN), and to find any relationships between the immunoexpression of 
      chemokines and chemokine receptors and renal interstitial lesions. Our study 
      revealed increased immunoexpression of tubulointerstitial MCP-1 (P < 0.02), 
      RANTES (P < 0.03) and interstitial CCR5+ cells (P < 0.05) in IgAN as compared 
      with MesProGN. In the renal tissue in patients with IgAN the intensity of 
      tubulointerstitial immunostaining of MCP-1 and the number of CCRI+ cells and 
      CCR5+ cells were significantly correlated with the renal interstitial cortical 
      volume, meanwhile in biopsy specimens from patients with MesProGN only 
      interstitial CCR5+ cells were positively correlated with the interstitial 
      cortical volume. In conclusion, these observations suggest that in the renal 
      tissue in IgAN patients MCP-1, RANTES and CCR5 are up-regulated as compared with 
      renal biopsy specimens from patients with MesProGN. Moreover, MCP-1 as well CCR5 
      and CCR1 positive cells may play a role in the interstitial processes leading to 
      fibrosis in IgAN, whereas in MesProGN CCR5-positive cells may participate in 
      interstitial lesions in renal tissue.
FAU - Wagrowska-Danilewicz, Malgorzata
AU  - Wagrowska-Danilewicz M
AD  - Department of Nephropathology, Chair of Pathomorphology, Medical University, 
      Lodz. emwude@poczta.onet.pl
FAU - Danilewicz, Marian
AU  - Danilewicz M
FAU - Stasikowska, Olga
AU  - Stasikowska O
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Pol J Pathol
JT  - Polish journal of pathology : official journal of the Polish Society of 
      Pathologists
JID - 9437432
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL3)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Chemokines, CC)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - Adult
MH  - Chemokine CCL2/biosynthesis
MH  - Chemokine CCL3
MH  - Chemokine CCL4
MH  - Chemokine CCL5/biosynthesis
MH  - Chemokines, CC/*biosynthesis
MH  - Female
MH  - Glomerulonephritis, IGA/*metabolism
MH  - Glomerulonephritis, Membranoproliferative/*metabolism
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Immunohistochemistry
MH  - Macrophage Inflammatory Proteins/biosynthesis
MH  - Male
MH  - Middle Aged
MH  - Receptors, Chemokine/*biosynthesis
MH  - Up-Regulation
EDAT- 2005/12/13 09:00
MHDA- 2006/01/13 09:00
CRDT- 2005/12/13 09:00
PHST- 2005/12/13 09:00 [pubmed]
PHST- 2006/01/13 09:00 [medline]
PHST- 2005/12/13 09:00 [entrez]
PST - ppublish
SO  - Pol J Pathol. 2005;56(3):121-6.