PMID- 16337208
OWN - NLM
STAT- MEDLINE
DCOM- 20070207
LR  - 20161124
IS  - 1525-2167 (Print)
IS  - 1532-2114 (Linking)
VI  - 7
IP  - 5
DP  - 2006 Oct
TI  - Baseline echocardiographic characteristics of heart failure patients enrolled in 
      a large European multicentre trial (CArdiac REsynchronisation Heart Failure 
      study).
PG  - 373-8
AB  - AIMS: Information on the prevalence and clinical, electrocardiographic and 
      echocardiographic inter-relationships of mechanical dyssynchrony among patients 
      with heart failure (HF) and left ventricular systolic dysfunction derives mainly 
      from relatively small studies. The CARE-HF trial provides the opportunity to 
      address these issues in a large population of patients with advanced HF. METHODS 
      AND RESULTS: The CARE-HF trial enrolled patients with New York Heart Association 
      (NYHA) class III or IV HF, with a QRS duration > or =120 ms, left ventricular 
      (LV) ejection fraction (EF) < or =35% and LV end diastolic diameter > or =30 mm/m 
      (height in m). Patients underwent a thorough echocardiographic evaluation, which 
      included assessment of LV structure, systolic function, mitral inflow pattern, 
      right ventricular (RV) dimensions and function, and interventricular mechanical 
      delay (IVMD) as an index of interventricular dyssynchrony. Echocardiographic 
      measurements were made in a Core Laboratory to ensure consistent quantitative 
      analysis. Of the 813 patients enrolled, 735 had a baseline echocardiographic 
      examination suitable for measurement. Overall patients had advanced LV 
      dysfunction (mean EF 25.5%) but few had a restrictive mitral filling pattern 
      (18%) and both the mean RV diameter and RV function were within normal limits. 
      Interventricular dyssynchrony defined as IVMD >40 ms was present in 455 patients 
      (62%). Clinical, electrocardiographic and standard echocardiographic variables 
      were only loosely associated with IVMD. CONCLUSIONS: Interventricular 
      dyssynchrony appears to be an independent characteristic of patients with 
      advanced HF, and is poorly related to clinical, electrocardiographic or standard 
      echocardiographic variable.
FAU - Ghio, Stefano
AU  - Ghio S
AD  - Division of Cardiology, IRCCS Policlinico S. Matteo, University Hospital, Pavia, 
      Italy. echolab@smatteo.pv.it
FAU - Freemantle, Nick
AU  - Freemantle N
FAU - Serio, Alessandra
AU  - Serio A
FAU - Magrini, Giulia
AU  - Magrini G
FAU - Scelsi, Laura
AU  - Scelsi L
FAU - Pasotti, Michele
AU  - Pasotti M
FAU - Cleland, John G F
AU  - Cleland JG
FAU - Tavazzi, Luigi
AU  - Tavazzi L
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20051205
PL  - England
TA  - Eur J Echocardiogr
JT  - European journal of echocardiography : the journal of the Working Group on 
      Echocardiography of the European Society of Cardiology
JID - 100890618
SB  - IM
MH  - Aged
MH  - Blood Flow Velocity
MH  - *Echocardiography, Doppler
MH  - Electrocardiography
MH  - Europe/epidemiology
MH  - Female
MH  - Heart Failure/*diagnostic imaging/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve Insufficiency/diagnostic imaging/physiopathology
MH  - Multivariate Analysis
MH  - Myocardial Contraction
MH  - Observer Variation
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Stroke Volume
MH  - Ventricular Dysfunction, Left/diagnostic imaging/physiopathology
MH  - Ventricular Function, Left
MH  - Ventricular Function, Right
EDAT- 2005/12/13 09:00
MHDA- 2007/02/08 09:00
CRDT- 2005/12/13 09:00
PHST- 2005/06/21 00:00 [received]
PHST- 2005/10/10 00:00 [revised]
PHST- 2005/10/20 00:00 [accepted]
PHST- 2005/12/13 09:00 [pubmed]
PHST- 2007/02/08 09:00 [medline]
PHST- 2005/12/13 09:00 [entrez]
AID - S1525-2167(05)00170-8 [pii]
AID - 10.1016/j.euje.2005.10.006 [doi]
PST - ppublish
SO  - Eur J Echocardiogr. 2006 Oct;7(5):373-8. doi: 10.1016/j.euje.2005.10.006. Epub 
      2005 Dec 5.