PMID- 16337860
OWN - NLM
STAT- MEDLINE
DCOM- 20060131
LR  - 20061115
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 163
IP  - 2
DP  - 2005 Dec
TI  - Insertion (8;11) in a renal oncocytoma with multifocal transformation to 
      chromophobe renal cell carcinoma.
PG  - 160-3
AB  - We report the case of a 43-year-old male with multiple tumor foci showing 
      microscopic features of chromophobe renal carcinoma (ChRCC) arising in an 
      oncocytoma. Conventional cytogenetics of fresh tumor cells and fluorescence in 
      situ hybridization (FISH) revealed the following abnormal karyotype: 
      46,XY,der(8)ins(8;11)(p?;q13),der(11)ins(8;11)inv(11)(q12?p15) with CCND1 (11q13) 
      rearrangement. To our knowledge, chromosome 8 has not been reported as a partner 
      involved in structural rearrangements of 11q13 in oncocytomas. FISH in paraffin 
      tissue sections revealed a rearrangement of CCND1 (11q13) in the oncocytoma 
      cells. The multiple foci of chromophobe carcinoma presented multiple copies of 
      CCND1, suggesting that they represented a transformation from oncocytoma into 
      ChRCC. There was immunohistochemical overexpression of CCND1 in both oncocytoma 
      and chromophobe carcinoma cells. In this case, the correlation of the microscopic 
      findings with changes in CCND1 gene associated to CCND1 overexpression in both 
      components suggest that the ChRCC would have originated from the preexisting 
      oncocytoma. It is not possible to detect, by cytogenetic techniques alone, if the 
      ChRCC component have also the CCND1 rearrangement in addition to the detected 
      polysomy. FISH techniques on paraffin tissue sections may help to identify 
      genetic aberrations such as CCND1 rearrangement in order to establish a diagnosis 
      of oncocytoma.
FAU - Salido, Marta
AU  - Salido M
AD  - Laboratori de Citogenetica i Biologia Molecular, Servei de Patologia, Hospital 
      del Mar, IMAS, Universitat Autonoma de Barcelona, Passeig Maritim 25-29, 
      Barcelona 08003, Spain. Msalido@imas.imim.es
FAU - Lloreta, Josep
AU  - Lloreta J
FAU - Melero, Carme
AU  - Melero C
FAU - Garcia, Mar
AU  - Garcia M
FAU - Placer, Jose
AU  - Placer J
FAU - Espinet, Blanca
AU  - Espinet B
FAU - Villa, Olaya
AU  - Villa O
FAU - Bielsa, Oscar
AU  - Bielsa O
FAU - Gelabert-Mas, Antoni
AU  - Gelabert-Mas A
FAU - Serrano, Sergi
AU  - Serrano S
FAU - Sole, Francesc
AU  - Sole F
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Adenoma, Oxyphilic/*genetics/pathology
MH  - Adult
MH  - Carcinoma, Renal Cell/*genetics/pathology
MH  - Cell Transformation, Neoplastic
MH  - Chromosome Banding
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 8
MH  - Cyclin D1/genetics
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Kidney Neoplasms/*genetics
MH  - Male
EDAT- 2005/12/13 09:00
MHDA- 2006/02/01 09:00
CRDT- 2005/12/13 09:00
PHST- 2005/02/14 00:00 [received]
PHST- 2005/04/19 00:00 [revised]
PHST- 2005/04/22 00:00 [accepted]
PHST- 2005/12/13 09:00 [pubmed]
PHST- 2006/02/01 09:00 [medline]
PHST- 2005/12/13 09:00 [entrez]
AID - S0165-4608(05)00234-7 [pii]
AID - 10.1016/j.cancergencyto.2005.04.016 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2005 Dec;163(2):160-3. doi: 
      10.1016/j.cancergencyto.2005.04.016.