PMID- 16339667
OWN - NLM
STAT- MEDLINE
DCOM- 20060713
LR  - 20191210
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1054
DP  - 2005
TI  - Sibling donor cord blood transplantation for thalassemia major: Experience of the 
      Sibling Donor Cord Blood Program.
PG  - 206-13
AB  - The Sibling Donor Cord Blood (SDCB) Program was initiated in 1998 as a resource 
      to collect, characterize, and release cord blood units (CBUs) from families 
      affected by malignant and nonmalignant disorders for transplantation. Families in 
      the United States were recruited by telephone after referrals by community and 
      academic physicians. Collection kits were mailed to prospective participants and 
      family members were instructed about CBU procurement from community hospitals and 
      shipping to a central laboratory. Data about the infant's delivery and CBU 
      harvest, CBU processing, prethaw characteristics, sterility, and human leukocyte 
      antigen (HLA) typing were collected. Standard outcome data were collected after 
      CBU release for transplantation. Descriptive analyses of CBU collections, 
      processing, release, and transplantation outcomes were performed. Currently, 1617 
      CBU collections have been processed from families with thalassemia (6%), sickle 
      cell disease (28%), malignant disorders (49%), and other rare hematological 
      disorders (17%). Thirty-two of 96 donor-recipient pairs with thalassemia major 
      were HLA identical and 14 have received cord blood transplantation, either alone 
      or in combination with bone marrow or peripheral blood progenitor cells (N = 4) 
      from the same donor. Eleven of the 14 survive free of thalassemia after 
      transplantation. These preliminary results confirm the feasibility and utility of 
      remote-site sibling donor cord blood collection and subsequent transplantation 
      for hematological disorders, with a very high rate of usage from a cord blood 
      bank dedicated to performing these unique collections. It was concluded that cord 
      blood transplantation from sibling donors represents a suitable alternative to 
      bone marrow transplantation.
FAU - Walters, Mark C
AU  - Walters MC
AD  - Children's Hospital & Research Center at Oakland, 747 52nd St., Oakland, CA 
      94609, USA. mwalters@mail.cho.org
FAU - Quirolo, Lynn
AU  - Quirolo L
FAU - Trachtenberg, Elizabeth T
AU  - Trachtenberg ET
FAU - Edwards, Sandie
AU  - Edwards S
FAU - Hale, Lisa
AU  - Hale L
FAU - Lee, Joanna
AU  - Lee J
FAU - Morton-Wiley, Joi
AU  - Morton-Wiley J
FAU - Quirolo, Keith
AU  - Quirolo K
FAU - Robertson, Shanda
AU  - Robertson S
FAU - Saba, Julie
AU  - Saba J
FAU - Lubin, Bert
AU  - Lubin B
LA  - eng
GR  - M01 RR001271/RR/NCRR NIH HHS/United States
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
SB  - IM
MH  - Anemia, Sickle Cell/surgery
MH  - Blood Banks/*organization & administration/statistics & numerical data
MH  - Bone Marrow Transplantation
MH  - Child
MH  - Cord Blood Stem Cell Transplantation/*statistics & numerical data
MH  - Disease-Free Survival
MH  - Follow-Up Studies
MH  - Graft vs Host Disease/epidemiology/prevention & control
MH  - Hematologic Diseases/surgery
MH  - Histocompatibility
MH  - Humans
MH  - Infant, Newborn
MH  - Life Tables
MH  - Living Donors
MH  - Neoplasms/surgery
MH  - Peripheral Blood Stem Cell Transplantation
MH  - Referral and Consultation
MH  - Siblings
MH  - Survival Analysis
MH  - Tissue and Organ Procurement/*organization & administration/statistics & 
      numerical data
MH  - Transplantation, Homologous/statistics & numerical data
MH  - United States
MH  - beta-Thalassemia/*surgery
EDAT- 2005/12/13 09:00
MHDA- 2006/07/14 09:00
CRDT- 2005/12/13 09:00
PHST- 2005/12/13 09:00 [pubmed]
PHST- 2006/07/14 09:00 [medline]
PHST- 2005/12/13 09:00 [entrez]
AID - 1054/1/206 [pii]
AID - 10.1196/annals.1345.025 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2005;1054:206-13. doi: 10.1196/annals.1345.025.