PMID- 16340249
OWN - NLM
STAT- MEDLINE
DCOM- 20060125
LR  - 20170124
IS  - 1010-4283 (Print)
IS  - 1010-4283 (Linking)
VI  - 27
IP  - 1
DP  - 2006
TI  - Preoperative serum hCGbeta as a prognostic marker in primary fallopian tube 
      carcinoma.
PG  - 43-9
AB  - OBJECTIVES: It was the aim of this study to evaluate the prognostic value of the 
      pretreatment serum concentrations of the beta-subunit of human chorionic 
      gonadotropin (hCGbeta), CA 125 and tumour-associated trypsin inhibitor (TATI) in 
      primary fallopian tube carcinoma (PFTC). METHODS: The pretreatment serum 
      concentrations of hCGbeta, CA 125 and TATI were analyzed in serum samples from 60 
      women with a mean age of 61 years, treated for PFTC between 1985 and 2000. Of the 
      91 patients treated during this period, 31 were excluded because no serum sample 
      was available. The patients were followed-up for recurrence and survival until 
      February 14, 2003. The prognostic value of the serum markers were compared with 
      those of stage, grade and histological type. RESULTS: The median survival time 
      was 27 months and the overall 5-year survival rate 33%. Stage and size of the 
      residual tumour (<1 vs. > or =1 cm) predicted both overall and disease-free 
      survival (p < 0.050). Histology (serous vs. others) (p = 0.023) also influenced 
      overall survival. Overall 5-year survival was 38% when serum hCGbeta was below 
      3.5 pmol/l, while it was 18% when the level was higher (p = 0.052). The 
      corresponding disease-free 5-year survival was 38 and 20%, respectively (p = 
      0.014). Patients with CA 125 values above 1,017 kU/l had an overall 5-year 
      survival of 39% as compared with 14% for those with lower values (p = 0.009), 
      while the disease-free survival was 37 and 23%, respectively (p = 0.096). Serum 
      TATI was not a prognostic marker. Serum concentrations of hCGbeta and CA 125 
      correlated significantly with stage (p = 0.049 and p = 0.050, respectively). In 
      multivariate Cox proportional hazards regression analysis, only hCGbeta, stage 
      and histology emerged as independent prognostic factors. CONCLUSIONS: Clearly 
      elevated serum concentrations of hCGbeta and CA 125 predict survival in fallopian 
      tube carcinoma, but in multivariate analyses, only hCGbeta is a prognostic factor 
      independent of stage and histology.
CI  - Copyright 2006 S. Karger AG, Basel.
FAU - Riska, A
AU  - Riska A
AD  - Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, 
      Finland.
FAU - Alfthan, H
AU  - Alfthan H
FAU - Finne, P
AU  - Finne P
FAU - Jalkanen, J
AU  - Jalkanen J
FAU - Sorvari, T
AU  - Sorvari T
FAU - Stenman, U H
AU  - Stenman UH
FAU - Leminen, A
AU  - Leminen A
LA  - eng
PT  - Journal Article
DEP - 20051208
PL  - Netherlands
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental 
      Biology and Medicine
JID - 8409922
RN  - 0 (CA-125 Antigen)
RN  - 0 (Chorionic Gonadotropin, beta Subunit, Human)
RN  - 50936-63-5 (Trypsin Inhibitor, Kazal Pancreatic)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - CA-125 Antigen/blood
MH  - Chorionic Gonadotropin, beta Subunit, Human/*blood
MH  - Disease-Free Survival
MH  - Fallopian Tube Neoplasms/*pathology
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Staging
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Trypsin Inhibitor, Kazal Pancreatic/blood
EDAT- 2005/12/13 09:00
MHDA- 2006/01/26 09:00
CRDT- 2005/12/13 09:00
PHST- 2005/04/15 00:00 [received]
PHST- 2005/08/11 00:00 [accepted]
PHST- 2005/12/13 09:00 [pubmed]
PHST- 2006/01/26 09:00 [medline]
PHST- 2005/12/13 09:00 [entrez]
AID - 90155 [pii]
AID - 10.1159/000090155 [doi]
PST - ppublish
SO  - Tumour Biol. 2006;27(1):43-9. doi: 10.1159/000090155. Epub 2005 Dec 8.