PMID- 16340850
OWN - NLM
STAT- MEDLINE
DCOM- 20060426
LR  - 20071115
IS  - 0761-8425 (Print)
IS  - 0761-8425 (Linking)
VI  - 22
IP  - 6 Pt 2
DP  - 2005 Dec
TI  - [Improved prognosis in non small cell lung cancer--myth or reality?].
PG  - 8S137-42
AB  - Some data suggest that survival in non small cell lung cancer (NSCLC) has 
      improved in the last ten years. A comparison between large prospective 
      therapeutic trials from 1979 to 2002 does show some progress but there are many 
      biases, especially the Will Rogers effect, where stage migration due to new 
      methods of diagnostic imaging and invasive staging procedures could improve 
      actuarial survival in each stage. Prospective randomised trials comparing older 
      and more recent treatments demonstrate some improvements, specifically 
      perioperative chemotherapy in stages I-IIIA, chemo-radiation in unresectable 
      stage III disease and new drugs in stage IV. However retrospective whole 
      population studies fail to show a significant improvement in survival. These 
      discrepancies could be explained by differences between whole populations and 
      those selected for clinical trials. Moreover, the results of the therapeutic 
      trials are not always applied in all unselected patients. In conclusion, NSCLC 
      survival can be improved in a selected population. To reproduce this in the whole 
      population all patients should be managed in accordance with the results of 
      recent trials.
FAU - Milleron, B
AU  - Milleron B
AD  - Unite Fonctionnelle d'Oncologie Thoracique, Hopital Tenon (CancerEst), Paris, 
      France. bernard.milleron@tnn.aphp.fr
FAU - Lavole, A
AU  - Lavole A
FAU - Gounant, V
AU  - Gounant V
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Amelioration du pronostic des cancers bronchiques non a petites cellules: mythe 
      ou realite?
PL  - France
TA  - Rev Mal Respir
JT  - Revue des maladies respiratoires
JID - 8408032
SB  - IM
MH  - Carcinoma, Non-Small-Cell Lung/*mortality/therapy
MH  - Humans
MH  - Lung Neoplasms/*mortality/therapy
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Randomized Controlled Trials as Topic
MH  - Survival Rate
RF  - 29
EDAT- 2005/12/13 09:00
MHDA- 2006/04/28 09:00
CRDT- 2005/12/13 09:00
PHST- 2005/12/13 09:00 [pubmed]
PHST- 2006/04/28 09:00 [medline]
PHST- 2005/12/13 09:00 [entrez]
AID - MDOI-RMR-12-2005-22-6-C2-0761-8425-101019-200509152 [pii]
PST - ppublish
SO  - Rev Mal Respir. 2005 Dec;22(6 Pt 2):8S137-42.