PMID- 16343070
OWN - NLM
STAT- MEDLINE
DCOM- 20060228
LR  - 20051213
IS  - 1478-3223 (Print)
IS  - 1478-3223 (Linking)
VI  - 25
IP  - 6
DP  - 2005 Dec
TI  - Influence of HLA compatibility and lymphocyte cross-matching on acute cellular 
      rejection following living donor adult liver transplantation.
PG  - 1182-8
AB  - BACKGROUND: Reports on the relevance of immunogenetic factors in living donor 
      adult liver transplantation (LDALT) are often conflicting or inconclusive. We 
      therefore investigated the human leukocyte antigen (HLA) mismatches, lymphocyte 
      crossmatch positivity, and the reactivity in mixed lymphocyte culture (MLC) in a 
      series of LDALT. METHODS: A total of 104 LDALT patients were studied. The minimum 
      follow-up was 12 months, and the graft survival rates were assessed. The 
      incidence of the most common complications was analyzed. And the influence of 
      HLA, the flow cytometric analysis findings, enhanced cytotoxic cross-matching and 
      MLC on graft survival, and acute rejection was also investigated. RESULTS: As a 
      result, 96 negative cross-matching and eight positive cross-matching cases were 
      identified. Positive cytotoxic cross-matching had a significant effect on graft 
      survival (P<0.05), while flow cytometric cross-matching also had an additional 
      effect on acute rejection (P<0.05). The MLC of the patients with three HLA 
      mismatches was significantly higher than the MLC of patients with zero HLA 
      mismatches. The incidence of acute cellular rejection (ACR) was higher in the 
      patients with three mismatches than in the other patients, and moderate rejection 
      only occurred in the patients with three mismatches. CONCLUSION: HLA mismatching 
      was not statistically associated with the overall graft survival after LDALT. The 
      graft failure rates were higher in the positive cross-matching cases and 
      therefore a strong immuosuppressant might be needed for positive cross-matching 
      cases.
FAU - Suehiro, Taketoshi
AU  - Suehiro T
AD  - Department of General Surgical Science, Graduate School of Medicine, Gunma 
      University, Maebashi, Japan. tsuehiro@med.gunma-u.ac.jp
FAU - Shimada, Mitsuo
AU  - Shimada M
FAU - Kishikawa, Keiji
AU  - Kishikawa K
FAU - Shimura, Tatsuo
AU  - Shimura T
FAU - Soejima, Yuji
AU  - Soejima Y
FAU - Yoshizumi, Tomoharu
AU  - Yoshizumi T
FAU - Hashimoto, Kohji
AU  - Hashimoto K
FAU - Mochida, Yasushi
AU  - Mochida Y
FAU - Maehara, Yoshihiko
AU  - Maehara Y
FAU - Kuwano, Hiroyuki
AU  - Kuwano H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Liver Int
JT  - Liver international : official journal of the International Association for the 
      Study of the Liver
JID - 101160857
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Blood Grouping and Crossmatching
MH  - Female
MH  - Graft Rejection/*immunology
MH  - Graft Survival/immunology
MH  - HLA Antigens/*analysis
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Liver Transplantation/*immunology
MH  - *Living Donors
MH  - Lymphocyte Culture Test, Mixed
MH  - Lymphocytes/*immunology
MH  - Male
EDAT- 2005/12/14 09:00
MHDA- 2006/03/01 09:00
CRDT- 2005/12/14 09:00
PHST- 2005/12/14 09:00 [pubmed]
PHST- 2006/03/01 09:00 [medline]
PHST- 2005/12/14 09:00 [entrez]
AID - LIV1160 [pii]
AID - 10.1111/j.1478-3231.2005.01160.x [doi]
PST - ppublish
SO  - Liver Int. 2005 Dec;25(6):1182-8. doi: 10.1111/j.1478-3231.2005.01160.x.