PMID- 16343086
OWN - NLM
STAT- MEDLINE
DCOM- 20060131
LR  - 20080528
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 16
IP  - 8
DP  - 2005 Dec
TI  - Comparison of the allergenicity of Actinidia deliciosa (kiwi fruit) and Actinidia 
      chinensis (gold kiwi).
PG  - 647-54
AB  - Actinidia chinensis (gold kiwi) is a newly available fruit which has been shown 
      to have in vitro immunoglobulin E (IgE) cross-reactivity with green kiwi. This is 
      the first study to investigate clinical reactivity of gold kiwi. Five patients 
      clinically allergic to green kiwi were investigated by skin test and double-blind 
      placebo controlled food challenge (DBPCFC) with gold kiwi fruit. IgE-binding 
      patterns of individual sera from the five challenged patients and a pool of sera 
      from a further nine patients with kiwi allergy were compared in the two fruits by 
      Western blotting. Cross reactivity of proteins in the two fruits was assessed by 
      inhibition of immunoblots and by IgE enzyme-linked immunosorbent assay (ELISA) 
      inhibition. Four of the five patients had a positive DBPCFC to gold kiwi. Western 
      blotting showed marked differences in the allergen patterns of green and gold 
      kiwi. However, inhibition of the immunoblots and ELISA assay reveals extensive 
      inhibition of IgE binding to proteins in each fruit by the alternative species. 
      Gold kiwi fruit is allergenic and patients allergic to green kiwi are at risk of 
      reacting to the gold kiwi fruit. Despite having different protein profiles and 
      IgE-binding patterns, the two species have proteins that extensively 
      cross-inhibit the binding to IgE.
FAU - Lucas, Jane S A
AU  - Lucas JS
AD  - Allergy and Inflammation Sciences, University of Southampton, Southampton, UK. 
      jlucas1@soton.ac.uk
FAU - Lewis, Stella A
AU  - Lewis SA
FAU - Trewin, Jennifer B
AU  - Trewin JB
FAU - Grimshaw, Kate E C
AU  - Grimshaw KE
FAU - Warner, John O
AU  - Warner JO
FAU - Hourihane, Jonathan O'B
AU  - Hourihane JO
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
EIN - Pediatr Allergy Immunol. 2006 Feb;17(1):82
MH  - *Actinidia/adverse effects/classification/immunology
MH  - Adult
MH  - Allergens/*immunology
MH  - Blotting, Western
MH  - Child
MH  - Cross Reactions
MH  - Double-Blind Method
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Food Hypersensitivity/*diagnosis/etiology/immunology
MH  - Humans
MH  - Immunoblotting
MH  - Immunoglobulin E/blood
MH  - Middle Aged
MH  - Skin Tests
EDAT- 2005/12/14 09:00
MHDA- 2006/02/01 09:00
CRDT- 2005/12/14 09:00
PHST- 2005/12/14 09:00 [pubmed]
PHST- 2006/02/01 09:00 [medline]
PHST- 2005/12/14 09:00 [entrez]
AID - PAI330 [pii]
AID - 10.1111/j.1399-3038.2005.00330.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2005 Dec;16(8):647-54. doi: 
      10.1111/j.1399-3038.2005.00330.x.