PMID- 16343803
OWN - NLM
STAT- MEDLINE
DCOM- 20060420
LR  - 20220310
IS  - 0360-3016 (Print)
IS  - 0360-3016 (Linking)
VI  - 64
IP  - 4
DP  - 2006 Mar 15
TI  - Radiotherapy for solitary extramedullary plasmacytoma in the head-and-neck 
      region: A dose greater than 45 Gy to the target volume improves the local 
      control.
PG  - 1013-7
AB  - PURPOSE: Our aim was to determine the dose to the clinical target volume (CTV) 
      required for solitary extramedullary plasmacytoma (EMP) in the head and neck 
      (HN). METHODS AND MATERIALS: Seventeen patients (15 Stage I and 2 Stage II) were 
      treated for HN EMP at our institution between 1979 and 2003. The mean 
      International Commission on Radiation Units (ICRU) dose prescribed to the CTV was 
      52.6 Gy (range, 40-65 Gy) over 24 fractions (range: 20-30). The Stage II patients 
      received neck irradiation doses of 40 and 60 Gy. A mean dose of 36.4 Gy was used 
      for 5 Stage I patients who received elective neck irradiation. Dose administrated 
      to the CTV was evaluated from dosimetric data or from planning films when 
      dosimetric data were not available. Two groups of patients were distinguished: 
      CTV covered with a dose greater than 40 Gy and CTV covered with a dose greater 
      than 45 Gy. RESULTS: The 5-year local control was 72.8%. It was 100% for patients 
      who received dose to the CTV > or = [DOSAGE ERROR CORRECTED] 45 Gy vs. 50% for 
      dose to the CTV <45 Gy (p = 0.034). The prognostic factor for 5-year 
      disease-specific survival (81.6%) was local control (p = 0.058). The prognostic 
      factors for disease-free survival (64.1%) were monoclonal immunoglobulin 
      secretion (p = 0.008) and a CTV dose > or = 45 Gy (p = 0.056) CONCLUSIONS: Local 
      control of EMP in the HN seems to be improved when the dose to the CTV is > or = 
      [DOSAGE ERROR CORRECTED] 45 Gy. A minimum dose of 45 Gy should be recommended to 
      the CTV.
FAU - Tournier-Rangeard, Laetitia
AU  - Tournier-Rangeard L
AD  - Department of Radiotherapy, Centre Alexis Vautrin, Nancy, France. 
      l.tournier@nancy.fnclcc.fr
FAU - Lapeyre, Michel
AU  - Lapeyre M
FAU - Graff-Caillaud, Pierre
AU  - Graff-Caillaud P
FAU - Mege, Alice
AU  - Mege A
FAU - Dolivet, Gilles
AU  - Dolivet G
FAU - Toussaint, Bruno
AU  - Toussaint B
FAU - Charra-Brunaud, Claire
AU  - Charra-Brunaud C
FAU - Hoffstetter, Sylvette
AU  - Hoffstetter S
FAU - Marchal, Christian
AU  - Marchal C
FAU - Peiffert, Didier
AU  - Peiffert D
LA  - eng
PT  - Journal Article
DEP - 20051215
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
EIN - Int J Radiat Oncol Biol Phys. 2006 May 1;65(1):314. Dosage error in published 
      abstract; MEDLINE/PubMed abstract corrected
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Disease-Free Survival
MH  - Female
MH  - Head and Neck Neoplasms/mortality/pathology/*radiotherapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Plasmacytoma/mortality/pathology/*radiotherapy
MH  - Radiotherapy Dosage
EDAT- 2005/12/14 09:00
MHDA- 2006/04/21 09:00
CRDT- 2005/12/14 09:00
PHST- 2005/06/28 00:00 [received]
PHST- 2005/08/26 00:00 [revised]
PHST- 2005/09/07 00:00 [accepted]
PHST- 2005/12/14 09:00 [pubmed]
PHST- 2006/04/21 09:00 [medline]
PHST- 2005/12/14 09:00 [entrez]
AID - S0360-3016(05)02709-4 [pii]
AID - 10.1016/j.ijrobp.2005.09.019 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2006 Mar 15;64(4):1013-7. doi: 
      10.1016/j.ijrobp.2005.09.019. Epub 2005 Dec 15.