PMID- 16344258
OWN - NLM
STAT- MEDLINE
DCOM- 20060914
LR  - 20220330
IS  - 1538-4721 (Print)
IS  - 1538-4721 (Linking)
VI  - 4
IP  - 4
DP  - 2005
TI  - Intraoperative (125)I Vicryl mesh brachytherapy after sublobar resection for 
      high-risk stage I non-small cell lung cancer.
PG  - 278-85
AB  - PURPOSE: To assess the feasibility and outcomes of (125)I Vicryl mesh 
      brachytherapy after sublobar resection in stage I non small cell lung cancer 
      (NSCLC) patients with poor pulmonary function. METHODS AND MATERIALS: Between 
      January 1997 and July 2004, patients with poor cardiopulmonary reserve who had 
      stage IA and IB (T1-2 N0 M0) NSCLC and a forced expiratory volume in 1s (FEV(1)) 
      of > micro=0.6L were considered for limited surgical resection either by an open 
      or video-assisted thoracoscopic procedure and for a subsequent (125)I Vicryl mesh 
      brachytherapy implant. Mediastinal and hilar lymph node staging was performed 
      routinely in all patients. After clear margins were obtained grossly and on 
      frozen section, a single-plane (125)I implant was designed to encompass a plane 
      consisting of the staple line and a 2-cm margin of surrounding visceral pleura. 
      The implant was introduced through the surgical incision and sutured to the 
      visceral pleura. A prescribed dose of 100-120 y was delivered to a volume within 
      0.5 cm rom the plane of the implant. Follow-up orthogonal films or CTs were 
      obtained for dosimetric analysis. Kaplan-Meier analyses were used to estimate the 
      local control, locoregional control, and overall survival rates. RESULTS: Of the 
      110 patients, 65 had stage IA and 45 had stage IB NSCLC. The mean preoperative 
      FEV(1) was 47% of the predicted volume. With a median follow-up of 11 months 
      (range 1-68 months), there were four recurrences within the radiation volume. The 
      estimated 5-year local (in-field) control, locoregional control, and overall 
      survival rates were 90%, 61%, and 18%, respectively. CONCLUSION: Vicryl mesh 
      brachytherapy after sublobar resection for high-risk stage I NSCLC patients is a 
      feasible procedure, which results in an excellent local (in-field) control rate.
FAU - Voynov, George
AU  - Voynov G
AD  - Department of Radiation Oncology, University of Pittsburgh Cancer Institute, 
      Pittsburgh, PA, USA.
FAU - Heron, Dwight E
AU  - Heron DE
FAU - Lin, Chyongchiou J
AU  - Lin CJ
FAU - Burton, Steven
AU  - Burton S
FAU - Chen, Alex
AU  - Chen A
FAU - Quinn, Annette
AU  - Quinn A
FAU - Santos, Ricardo
AU  - Santos R
FAU - Colonias, Athanasios
AU  - Colonias A
FAU - Landreneau, Rodney J
AU  - Landreneau RJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Brachytherapy
JT  - Brachytherapy
JID - 101137600
RN  - 0 (Iodine Radioisotopes)
RN  - 34346-01-5 (Polyglactin 910)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Brachytherapy
MH  - Carcinoma, Non-Small-Cell 
      Lung/pathology/physiopathology/radiotherapy/surgery/*therapy
MH  - Combined Modality Therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Forced Expiratory Volume
MH  - Humans
MH  - *Intraoperative Care
MH  - Iodine Radioisotopes/administration & dosage/*therapeutic use
MH  - Lung Neoplasms/pathology/physiopathology/radiotherapy/surgery/*therapy
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/prevention & control
MH  - Neoplasm Staging
MH  - *Pneumonectomy/adverse effects/methods
MH  - Polyglactin 910/administration & dosage/*therapeutic use
MH  - Risk Factors
MH  - Survival Analysis
MH  - Thoracic Surgery, Video-Assisted
MH  - Thoracotomy
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2005/12/14 09:00
MHDA- 2006/09/15 09:00
CRDT- 2005/12/14 09:00
PHST- 2005/01/06 00:00 [received]
PHST- 2005/02/25 00:00 [revised]
PHST- 2005/03/08 00:00 [accepted]
PHST- 2005/12/14 09:00 [pubmed]
PHST- 2006/09/15 09:00 [medline]
PHST- 2005/12/14 09:00 [entrez]
AID - S1538-4721(05)00100-5 [pii]
AID - 10.1016/j.brachy.2005.03.007 [doi]
PST - ppublish
SO  - Brachytherapy. 2005;4(4):278-85. doi: 10.1016/j.brachy.2005.03.007.