PMID- 1634804
OWN - NLM
STAT- MEDLINE
DCOM- 19920825
LR  - 20190510
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 166
IP  - 2
DP  - 1992 Aug
TI  - Role of interferon-gamma in experimental gram-negative sepsis.
PG  - 331-5
AB  - To study the role of interferon-gamma (IFN-gamma) in gram-negative shock, 
      mortality was compared in mice receiving either a monoclonal antibody to 
      IFN-gamma (H22) or an irrelevant monoclonal antibody (L2-3D9) before or after an 
      LD90 dose of Escherichia coli O111:B4. H22 given either 1 h before or 0.5 h after 
      bacterial challenge protected mice from death (mortality at 48 h, 28% vs. 83%, P 
      less than .001). Serum tumor necrosis factor-alpha (TNF alpha) levels and 
      bacterial counts in blood and organs (liver, spleen, heart, and brain) were 
      similar in H22-treated animals and controls. The peak serum TNF alpha levels were 
      95.7 +/- 16.4 ng/mL and 80.7 +/- 14.9 ng/mL in the H22 and control groups, 
      respectively. These results indicate that IFN-gamma plays a significant role in 
      the pathogenesis of gram-negative sepsis.
FAU - Silva, A T
AU  - Silva AT
AD  - Department of Infectious Diseases and Bacteriology, Hammersmith Hospital, London, 
      United Kingdom.
FAU - Cohen, J
AU  - Cohen J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/*therapeutic use
MH  - Bacteremia/*etiology/immunology/therapy
MH  - Colony Count, Microbial
MH  - Escherichia coli/growth & development/immunology
MH  - Escherichia coli Infections/etiology/immunology
MH  - Gram-Negative Bacterial Infections/*etiology/immunology/therapy
MH  - Interferon-gamma/immunology/*physiology
MH  - Male
MH  - Mice
MH  - Tumor Necrosis Factor-alpha/analysis/immunology
EDAT- 1992/08/01 00:00
MHDA- 1992/08/01 00:01
CRDT- 1992/08/01 00:00
PHST- 1992/08/01 00:00 [pubmed]
PHST- 1992/08/01 00:01 [medline]
PHST- 1992/08/01 00:00 [entrez]
AID - 10.1093/infdis/166.2.331 [doi]
PST - ppublish
SO  - J Infect Dis. 1992 Aug;166(2):331-5. doi: 10.1093/infdis/166.2.331.