PMID- 1635160
OWN - NLM
STAT- MEDLINE
DCOM- 19920825
LR  - 20061115
IS  - 0485-1439 (Print)
IS  - 0485-1439 (Linking)
VI  - 33
IP  - 2
DP  - 1992 Feb
TI  - [Analysis of the GPIIb and GPIIIa genes in patients with Glanzmann's 
      thrombasthenia].
PG  - 133-8
AB  - Glanzmann's thrombasthenia (GT) is an autosomal recessive bleeding disorder due 
      to a deficiency or abnormality of glycoproteins (GPs) IIb and IIIa, but its 
      genetic basis remains to be determined. We analyzed the genes for GPIIb and 
      3'GPIIIa in 3 patients with GT and in 7 control subjects by Southern blot. No 
      large deletions or insertions were detected in these genes in any patient with 
      GT. Furthermore, the GPIIb and GPIIIa mRNAs derived from the platelets of 
      patients with GT could be amplified using the reverse transcriptase-polymerase 
      chain reaction (RT-PCR). This finding indicates that the mRNAs of the patients 
      with GT are considered to be normally transcribed. The molecular defects of the 
      GPIIb.
FAU - Yasunaga, M
AU  - Yasunaga M
AD  - Department of Clinical Laboratory Medicine, Kobe University School of Medicine.
FAU - Ryo, R
AU  - Ryo R
FAU - Adachi, M
AU  - Adachi M
FAU - Sugano, W
AU  - Sugano W
FAU - Yoshida, A
AU  - Yoshida A
FAU - Nakayama, K
AU  - Nakayama K
FAU - Saigo, K
AU  - Saigo K
FAU - Yasunaga, K
AU  - Yasunaga K
FAU - Yamaguchi, N
AU  - Yamaguchi N
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Rinsho Ketsueki
JT  - [Rinsho ketsueki] The Japanese journal of clinical hematology
JID - 2984782R
RN  - 0 (Platelet Membrane Glycoproteins)
SB  - IM
MH  - Blotting, Southern
MH  - Female
MH  - Gene Amplification
MH  - *Genes
MH  - Humans
MH  - Male
MH  - Platelet Membrane Glycoproteins/*genetics
MH  - Polymerase Chain Reaction
MH  - Thrombasthenia/*genetics
EDAT- 1992/02/01 00:00
MHDA- 1992/02/01 00:01
CRDT- 1992/02/01 00:00
PHST- 1992/02/01 00:00 [pubmed]
PHST- 1992/02/01 00:01 [medline]
PHST- 1992/02/01 00:00 [entrez]
PST - ppublish
SO  - Rinsho Ketsueki. 1992 Feb;33(2):133-8.