PMID- 16351655
OWN - NLM
STAT- MEDLINE
DCOM- 20060323
LR  - 20061030
IS  - 0919-8172 (Print)
IS  - 0919-8172 (Linking)
VI  - 12
IP  - 11
DP  - 2005 Nov
TI  - Is there a possible correlation between chromosomal variants and spermatogenesis?
PG  - 984-9
AB  - AIM: Heterochromatin polymorphism is considered a variant of a normal karyotype 
      but is more frequent in infertile men. The aim of this study was to evaluate the 
      correlation between heterochromatic variants and male infertility and to discuss 
      the possible mechanisms of how heterochromatic polymorphism might affect 
      spermatogenesis. METHODS: Cytogenetic analysis was undertaken in 210 infertile 
      males who had been taken into assisted reproductive techniques and in 183 men 
      with proven fertility. Additionally, C-banding was performed in men with 
      heterochromatin polymorphism. Sperm fluorescence in situ hybridization (FISH) was 
      applied in 54 men with normal karyotype presenting either normal or abnormal 
      sperm parameters as well as in 8 men with heterochromatin polymorphism. The 
      outcomes of assisted reproductive techniques were compared between infertile men 
      with normal karyotype and men with heterochromatin polymorphism. RESULTS: The 
      incidence of heterochromatin polymorphism was higher in infertile men. The most 
      frequent chromosome involved in heterochromatin polymorphism was chromosome 9. 
      Sperm FISH analysis revealed an increased rate of aneuploidy in men with 
      heterochromatin polymorphism. Laboratory and clinical outcomes in assisted 
      reproductive techniques were compromised in men with heterochromatin 
      polymorphism. CONCLUSIONS: An increased rate of heterochromatin polymorphism in 
      infertile males seems to be more than an incidental finding, and must not be 
      considered as a normal variant. Polymorphic heterochromatin may have deleterious 
      effects on the genetic constitution of spermatozoa. More attention must be 
      directed to infertile men with heterochromatin polymorphism.
FAU - Yakin, Kayhan
AU  - Yakin K
AD  - Assisted Reproduction Unit, American Hospital of Istanbul, Istanbul, Turkey. 
      kayhany@amerikanhastanesi.com.tr
FAU - Balaban, Basak
AU  - Balaban B
FAU - Urman, Bulent
AU  - Urman B
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Int J Urol
JT  - International journal of urology : official journal of the Japanese Urological 
      Association
JID - 9440237
RN  - 0 (Heterochromatin)
SB  - IM
MH  - Adult
MH  - Aneuploidy
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Y
MH  - Cytogenetic Analysis
MH  - Female
MH  - Heterochromatin/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infertility, Male/*genetics
MH  - Male
MH  - *Polymorphism, Genetic
MH  - Reproductive Techniques, Assisted
MH  - Spermatogenesis/*genetics
MH  - Spermatozoa/physiology
EDAT- 2005/12/15 09:00
MHDA- 2006/03/24 09:00
CRDT- 2005/12/15 09:00
PHST- 2005/12/15 09:00 [pubmed]
PHST- 2006/03/24 09:00 [medline]
PHST- 2005/12/15 09:00 [entrez]
AID - IJU1185 [pii]
AID - 10.1111/j.1442-2042.2005.01185.x [doi]
PST - ppublish
SO  - Int J Urol. 2005 Nov;12(11):984-9. doi: 10.1111/j.1442-2042.2005.01185.x.