PMID- 16352301
OWN - NLM
STAT- MEDLINE
DCOM- 20060802
LR  - 20151119
IS  - 0013-9351 (Print)
IS  - 0013-9351 (Linking)
VI  - 101
IP  - 3
DP  - 2006 Jul
TI  - Estimations of past male and female serum concentrations of biomarkers of 
      persistent organochlorine pollutants and their impact on fecundability estimates.
PG  - 387-94
AB  - Persistent organochlorine pollutants (POPs) have been suggested to have negative 
      effects on a number of hormonal systems. Several studies performed 
      retrospectively have reported a possible association between POP exposure and 
      fertility, measured as time to pregnancy (TTP). However, these studies lack 
      biomarkers of exposure at the time when the women tried to conceive. It has 
      previously been found that past female serum concentrations of 
      2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) can be estimated using a complex decay 
      model, assuming that the biological half-life is 5 years, the yearly 
      environmental reduction of the compound has been 3% since 1976, and the reduction 
      of body burden due to lactation is 20% for periods up to 6 months and 30% for 
      periods exceeding 6 months. In the present study, it is established that the 
      model is valid also for estimations of past male serum concentrations of CB-153. 
      Furthermore, the complex decay model was found to be useful also for estimating 
      past serum concentrations of 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene 
      (p,p'-DDE), assuming that the biological half-life of the compound is 8 years, 
      the yearly reduction between 1971 and 1981 was 20% and after that 9%, and the 
      reduction of body burden due to lactation is the same as that for CB-153. 
      However, even though the estimated past serum concentrations of CB-153 and 
      p,p'-DDE were found to be better proxy measures of actual past concentrations 
      than current serum concentrations, there was little change in the rank order of 
      the population investigated. Thus, the effect estimate for TTP was similar for 
      both proxy measures when using categorized measures of exposure.
FAU - Axmon, Anna
AU  - Axmon A
AD  - Division of Occupational and Environmental Medicine and Psychiatric Epidemiology, 
      Lund University Hospital, Lund 221 85, Sweden. anna.axmon@med.lu.se
FAU - Rignell-Hydbom, Anna
AU  - Rignell-Hydbom A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051213
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Biomarkers)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Biomarkers/blood
MH  - Dichlorodiphenyl Dichloroethylene/blood
MH  - Environmental Exposure/*analysis
MH  - Environmental Pollutants/analysis/*blood
MH  - Female
MH  - Fertility/*drug effects/physiology
MH  - Food Chain
MH  - Half-Life
MH  - Humans
MH  - Hydrocarbons, Chlorinated/analysis/*blood
MH  - Male
MH  - Models, Biological
MH  - Polychlorinated Biphenyls/analysis/blood
MH  - Pregnancy/blood/*physiology
MH  - Seafood/analysis
MH  - Sweden
MH  - Time Factors
EDAT- 2005/12/15 09:00
MHDA- 2006/08/03 09:00
CRDT- 2005/12/15 09:00
PHST- 2005/06/15 00:00 [received]
PHST- 2005/09/27 00:00 [revised]
PHST- 2005/10/07 00:00 [accepted]
PHST- 2005/12/15 09:00 [pubmed]
PHST- 2006/08/03 09:00 [medline]
PHST- 2005/12/15 09:00 [entrez]
AID - S0013-9351(05)00150-7 [pii]
AID - 10.1016/j.envres.2005.10.005 [doi]
PST - ppublish
SO  - Environ Res. 2006 Jul;101(3):387-94. doi: 10.1016/j.envres.2005.10.005. Epub 2005 
      Dec 13.