PMID- 16352421
OWN - NLM
STAT- MEDLINE
DCOM- 20070613
LR  - 20201219
IS  - 0923-1811 (Print)
IS  - 0923-1811 (Linking)
VI  - 42
IP  - 1
DP  - 2006 Apr
TI  - Differential role of MAPK signaling in human dendritic cell maturation and 
      Th1/Th2 engagement.
PG  - 1-11
AB  - Dendritic cells (DCs) are potent antigen-presenting cells that can stimulate 
      resting T cells in the primary immune response. During the maturation process, 
      immature DCs lose their ability to internalize antigens and they acquire the 
      capacity to present antigens to naive T cells. Many observations have suggested 
      that distinct DC subsets might differentially regulate Th responses. However, 
      recent reports suggest that specific subsets of either murine or human DCs 
      cultured in vitro with different stimuli respond with great plasticity in terms 
      of both gene expression and cytokine secretion. Thus, the microenvironment of DCs 
      may determine the nature of mature DCs and the subsequent immune response. The 
      mechanism by which the character of DCs is determined is unknown. The in vitro 
      maturation process of human monocyte-derived DCs (MoDC) can be initiated by 
      various stimuli. Many stimuli induce phosphorylation of extracellular 
      signal-regulated kinases (ERK), c-Jun N-terminal kinases (JNK), and p38 MAPK in 
      DCs during maturation. Such kinase-specific inhibitors help to reveal the 
      functions of MAPKs in the maturation of human MoDCs. Recent studies suggest that 
      three MAPK signaling pathways differentially regulate all aspects of phenotypic 
      maturation, cytokine production, and functional maturation of MoDCs. Thus, 
      distinct maturation of DCs may be induced by modulating the balance of 
      phosphorylation of the three MAPKs. In this review, we summarize the role of MAPK 
      signaling pathways in the maturation of human MoDCs.
FAU - Nakahara, Takeshi
AU  - Nakahara T
AD  - Department of Dermatology, Graduate School of Medical Sciences, Kyushu 
      University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan.
FAU - Moroi, Yoichi
AU  - Moroi Y
FAU - Uchi, Hiroshi
AU  - Uchi H
FAU - Furue, Masutaka
AU  - Furue M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20051213
PL  - Netherlands
TA  - J Dermatol Sci
JT  - Journal of dermatological science
JID - 9011485
RN  - 0 (Cytokines)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Cell Differentiation
MH  - Cytokines/immunology/metabolism
MH  - Dendritic Cells/cytology/immunology/*metabolism
MH  - Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors/metabolism
MH  - Humans
MH  - JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors/metabolism
MH  - *MAP Kinase Signaling System
MH  - Phosphorylation
MH  - Th1 Cells/*immunology
MH  - Th2 Cells/*immunology
MH  - p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors/metabolism
RF  - 55
EDAT- 2005/12/15 09:00
MHDA- 2007/06/15 09:00
CRDT- 2005/12/15 09:00
PHST- 2005/09/23 00:00 [received]
PHST- 2005/11/09 00:00 [accepted]
PHST- 2005/12/15 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2005/12/15 09:00 [entrez]
AID - S0923-1811(05)00318-X [pii]
AID - 10.1016/j.jdermsci.2005.11.004 [doi]
PST - ppublish
SO  - J Dermatol Sci. 2006 Apr;42(1):1-11. doi: 10.1016/j.jdermsci.2005.11.004. Epub 
      2005 Dec 13.