PMID- 16354185
OWN - NLM
STAT- MEDLINE
DCOM- 20060126
LR  - 20081121
IS  - 0022-202X (Print)
IS  - 0022-202X (Linking)
VI  - 125
IP  - 6
DP  - 2005 Dec
TI  - Hyperproduction of IFN-gamma by CpG oligodeoxynucleotide-induced exacerbation of 
      atopic dermatitis-like skin lesion in some NC/Nga mice.
PG  - 1156-62
AB  - Under conventional conditions, NC/Nga mice spontaneously develop an atopic 
      dermatitis (AD)-like skin lesion accompanied by immunoglobulin E (IgE) 
      hyperproduction and the expression of T helper 2 (Th2) cytokines. CpG DNA 
      activates a strong interferon-gamma (IFN-gamma)-dominated T helper 1 (Th1) 
      response, while inhibiting Th2-dependent allergies. In this study, we examined 
      whether CpG oligodeoxynucleotide (ODN) could prevent the development of the skin 
      lesions in NC/Nga mice. Sixteen of 26 NC/Nga mice did not exhibit dermatitis 
      after CpG ODN was administered intraperitoneally every 2 wk for a total of five 
      times. CpG ODN administration induced IFN-gamma production, which inhibited the 
      production of Th2 cytokines (interleukin (IL)-4, IL-5, and IL-13) in both spleen 
      and lymph node cells and culminated in a decrease in the serum IgE level. These 
      data suggest that the CpG ODN has a therapeutic effect against AD; however, some 
      mice (10 of 26) treated with CpG ODN exhibited an exacerbation of dermatitis 
      accompanied by the hyperproduction of IFN-gamma, although Th2 cytokines were 
      suppressed. These results suggest that the suppression of Th2 cytokines may not 
      completely prevent dermatitis and that IFN-gamma may play a role in developing 
      dermatitis in some NC/Nga mice.
FAU - Takakura, Momoko
AU  - Takakura M
AD  - Department of Environmental Immuno-Dermatology, Yokohama City University Graduate 
      School of Medicine, Yokohama, Japan.
FAU - Takeshita, Fumihiko
AU  - Takeshita F
FAU - Aihara, Michiko
AU  - Aihara M
FAU - Xin, Ke-Qin
AU  - Xin KQ
FAU - Ichino, Motohide
AU  - Ichino M
FAU - Okuda, Kenji
AU  - Okuda K
FAU - Ikezawa, Zenro
AU  - Ikezawa Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
RN  - 0 (Cytokines)
RN  - 0 (Dinucleoside Phosphates)
RN  - 0 (Oligodeoxyribonucleotides)
RN  - 2382-65-2 (cytidylyl-3'-5'-guanosine)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Cytokines/immunology
MH  - Dermatitis, Atopic/*genetics/*immunology/pathology/prevention & control
MH  - *Dinucleoside Phosphates
MH  - Disease Models, Animal
MH  - Immunoglobulin E/*blood
MH  - Interferon-gamma/biosynthesis/*immunology
MH  - Lymphocytes/immunology
MH  - Mice
MH  - Mice, Mutant Strains
MH  - Oligodeoxyribonucleotides/*pharmacology
MH  - Skin Diseases/immunology/pathology
MH  - Spleen/immunology
EDAT- 2005/12/16 09:00
MHDA- 2006/01/27 09:00
CRDT- 2005/12/16 09:00
PHST- 2005/12/16 09:00 [pubmed]
PHST- 2006/01/27 09:00 [medline]
PHST- 2005/12/16 09:00 [entrez]
AID - S0022-202X(15)32570-7 [pii]
AID - 10.1111/j.0022-202X.2005.23928.x [doi]
PST - ppublish
SO  - J Invest Dermatol. 2005 Dec;125(6):1156-62. doi: 
      10.1111/j.0022-202X.2005.23928.x.