PMID- 16356676
OWN - NLM
STAT- MEDLINE
DCOM- 20060427
LR  - 20121115
IS  - 0731-7085 (Print)
IS  - 0731-7085 (Linking)
VI  - 40
IP  - 3
DP  - 2006 Feb 24
TI  - LC/MS fingerprinting of Shenmai injection: a novel approach to quality control of 
      herbal medicines.
PG  - 591-7
AB  - Chromatographic fingerprinting has been recommended as a potential and reliable 
      strategy for the quality control of herbal medicines. Although varieties of 
      chromatographic techniques, particularly HPLC, have been widely employed, 
      hyphenated chromatographic approach has not been sufficiently exploited in 
      chromatographic fingerprinting. In this work, LC/MS fingerprinting of Shenmai 
      injection was developed. Thirty ginsenosides as well as seven ophioponins were 
      selected to construct the LC/MS fingerprint using selective ion monitoring (SIM) 
      mode, while previous HPLC fingerprint [H.J. Zhang, Y.J. Wu, Y.Y. Cheng, J. Pharm. 
      Biomed. Anal. 31 (2003) 175-183] only represents the ginsenosides. Subsequently, 
      the proposed LC/MS fingerprints were applied to identifying the product 
      manufacturers. All the samples were accurately classified based on their LC/MS 
      fingerprints in conjunction with principal components analysis (PCA). This study 
      would be potentially helpful to improve the quality control ability of 
      fingerprinting-based strategy for complex herbal medicines.
FAU - Xiaohui, Fan
AU  - Xiaohui F
AD  - Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, 
      Zhejiang University, Hangzhou 310027, PR China.
FAU - Yi, Wang
AU  - Yi W
FAU - Yiyu, Cheng
AU  - Yiyu C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051213
PL  - England
TA  - J Pharm Biomed Anal
JT  - Journal of pharmaceutical and biomedical analysis
JID - 8309336
RN  - 0 (Central Nervous System Agents)
RN  - 0 (Drug Combinations)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Ginsenosides)
RN  - 0 (Indicators and Reagents)
RN  - 0 (Pharmaceutical Solutions)
RN  - 0 (Plant Extracts)
RN  - 0 (fructus schizandrae, radix ginseng, radix ophiopogonis drug combination)
SB  - IM
MH  - Central Nervous System Agents/analysis
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Drug Combinations
MH  - Drugs, Chinese Herbal/*analysis
MH  - Ginsenosides/analysis
MH  - Indicators and Reagents
MH  - Mass Spectrometry/*methods
MH  - Pharmaceutical Solutions/analysis
MH  - Plant Extracts/*analysis
MH  - Quality Control
MH  - Reproducibility of Results
EDAT- 2005/12/17 09:00
MHDA- 2006/04/28 09:00
CRDT- 2005/12/17 09:00
PHST- 2005/06/04 00:00 [received]
PHST- 2005/10/20 00:00 [revised]
PHST- 2005/10/21 00:00 [accepted]
PHST- 2005/12/17 09:00 [pubmed]
PHST- 2006/04/28 09:00 [medline]
PHST- 2005/12/17 09:00 [entrez]
AID - S0731-7085(05)00685-0 [pii]
AID - 10.1016/j.jpba.2005.10.036 [doi]
PST - ppublish
SO  - J Pharm Biomed Anal. 2006 Feb 24;40(3):591-7. doi: 10.1016/j.jpba.2005.10.036. 
      Epub 2005 Dec 13.