PMID- 16358500
OWN - NLM
STAT- MEDLINE
DCOM- 20061024
LR  - 20201209
IS  - 0374-9096 (Print)
IS  - 0374-9096 (Linking)
VI  - 39
IP  - 3
DP  - 2005 Jul
TI  - [Antibiotic resistance in Helicobacter pylori and molecular methods for the 
      detection of resistance].
PG  - 399-408
AB  - Helicobacter pylori which is the major agent causing peptic ulcer, gastric cancer 
      and gastric lymphoma, is identified as a class I carcinogen. Invasive and 
      non-invasive tests have been used in the diagnosis of H. pylori infection. 
      Clarithromycin resistance in H. pylori strains is increasing nowadays, thus 
      leading to failures in eradication therapy. Fluorescence in situ hybridization 
      (FISH) method which can simultaneously detect the presence of H. pylori and 
      clarithromycin resistance is a non-culture dependent molecular technique. In this 
      review article the prevalence and clinical outcome of antibiotic resistance in H. 
      pylori, molecular mechanisms of the resistance and molecular methods to detect 
      the resistance, with priority of FISH technique have been discussed.
FAU - Demiray, Ebru
AU  - Demiray E
AD  - Dokuz Eylul Universitesi Tip Fakultesi, Mikrobiyoloji ve Klinik Mikrobiyoloji 
      Anabilim Dali, Izmir.
FAU - Yilmaz, Ozlem
AU  - Yilmaz O
LA  - tur
PT  - Journal Article
PT  - Review
TT  - Helicobacter pylori'de antibiyotik direnci ve direncin saptanmasinda kullanilan 
      molekuler yontemler.
PL  - Turkey
TA  - Mikrobiyol Bul
JT  - Mikrobiyoloji bulteni
JID - 7503830
RN  - 0 (Anti-Bacterial Agents)
RN  - H1250JIK0A (Clarithromycin)
SB  - IM
MH  - Anti-Bacterial Agents/*pharmacology/therapeutic use
MH  - Clarithromycin/pharmacology/therapeutic use
MH  - *Drug Resistance, Bacterial/genetics
MH  - Helicobacter Infections/complications/drug therapy/*microbiology
MH  - Helicobacter pylori/*drug effects/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma/microbiology
MH  - Stomach Neoplasms/microbiology
MH  - Stomach Ulcer/complications/drug therapy/*microbiology
RF  - 31
EDAT- 2005/12/20 09:00
MHDA- 2006/10/25 09:00
CRDT- 2005/12/20 09:00
PHST- 2005/12/20 09:00 [pubmed]
PHST- 2006/10/25 09:00 [medline]
PHST- 2005/12/20 09:00 [entrez]
PST - ppublish
SO  - Mikrobiyol Bul. 2005 Jul;39(3):399-408.