PMID- 16358945
OWN - NLM
STAT- MEDLINE
DCOM- 20060131
LR  - 20051219
VI  - 50
DP  - 2005
TI  - Application of specific cytologic, cytogenetic and molecular-cytogenetic 
      techniques for the characterization of solid tumors.
PG  - 91-6
AB  - Investigations of solid tumors have shown that a very specific characterization 
      of aberrant tissues can best be performed using a combination of cytologic, 
      cytogenetic and molecular-cytogenetic methods. Thus, cytological analyses may 
      serve to examine various features of tumors cultivated in vitro, e.g. growth 
      peculiarities, cell morphology, specific details of cell division and mitotic 
      rates, and anomalies of the spindle apparatus. Besides, chromosomal diagnostics 
      characterizing non-specific aberrations focuses on the pathological karyotype and 
      its evolution and heterogeneity, as well as on the development of secondary 
      chromosomal aberrations. In the field of molecular-cytogenetic diagnostics we 
      emphasize particularly the combination of metaphase and interphase analyses and 
      the investigation of specific structural aberrations by fluorescence in situ 
      hybridization (FISH). In contrast to the method of comparative genomic 
      hybridization (CGH), the spectrum of applications for both methods is discussed. 
      The findings described in this paper were obtained primarily from the analysis of 
      68 tumors of the urogenital tract (20 kidney tumors, 33 bladder tumors, 15 testis 
      tumors).
FAU - Schwanitz, G
AU  - Schwanitz G
AD  - Institute of Human Genetics, University of Bonn, Germany. raff@uni-bonn.de
FAU - Raff, R
AU  - Raff R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Poland
TA  - Rocz Akad Med Bialymst
JT  - Roczniki Akademii Medycznej w Bialymstoku (1995)
JID - 9515551
SB  - IM
MH  - *Cytogenetic Analysis
MH  - Cytological Techniques
MH  - Humans
MH  - Medical Oncology
MH  - *Molecular Biology
MH  - Neoplasms/*genetics/*pathology
RF  - 12
EDAT- 2005/12/20 09:00
MHDA- 2006/02/01 09:00
CRDT- 2005/12/20 09:00
PHST- 2005/12/20 09:00 [pubmed]
PHST- 2006/02/01 09:00 [medline]
PHST- 2005/12/20 09:00 [entrez]
PST - ppublish
SO  - Rocz Akad Med Bialymst. 2005;50:91-6.