PMID- 16359346
OWN - NLM
STAT- MEDLINE
DCOM- 20060427
LR  - 20220317
IS  - 0815-9319 (Print)
IS  - 0815-9319 (Linking)
VI  - 20 Suppl
DP  - 2005 Dec
TI  - CYP2C19 genotype and the PPIs--focus on rabeprazole.
PG  - S22-8
AB  - Amongst all the proton pump inhibitors (PPI), the hepatic metabolism of 
      rabeprazole is least dependent on the CYP4502C19 system. Rabeprazole is therefore 
      the PPI least affected by CYP4502C19 genetic polymorphism. This unique feature of 
      rabeprazole complements rabeprazole's fast onset of action, and may lead to 
      profound and consistent inhibition of gastric acid secretion in the treatment of 
      acid-related disorders.
FAU - Lim, P W Y
AU  - Lim PW
AD  - Eisai Co., Ltd, c/o Eisai Asia Regional Services Pte Ltd, Singapore. 
      p-lim@hhc.eisai.co.jp
FAU - Goh, K L
AU  - Goh KL
FAU - Wong, B C Y
AU  - Wong BC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Benzimidazoles)
RN  - 0 (Proton Pump Inhibitors)
RN  - 32828355LL (Rabeprazole)
RN  - EC 1.- (Mixed Function Oxygenases)
RN  - EC 1.14.14.1 (Aryl Hydrocarbon Hydroxylases)
RN  - EC 1.14.14.1 (CYP2C19 protein, human)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP2C19)
RN  - EC 3.6.1.- (Adenosine Triphosphatases)
RN  - EC 3.6.3.14 (Proton-Translocating ATPases)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles
MH  - Adenosine Triphosphatases/antagonists & inhibitors
MH  - Anti-Ulcer Agents/*metabolism/*therapeutic use
MH  - Aryl Hydrocarbon Hydroxylases/*genetics/metabolism
MH  - Benzimidazoles/*metabolism/*therapeutic use
MH  - Cytochrome P-450 CYP2C19
MH  - Gastroesophageal Reflux/*drug therapy/ethnology
MH  - Genotype
MH  - Helicobacter Infections/*drug therapy
MH  - *Helicobacter pylori
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Mixed Function Oxygenases/*genetics/metabolism
MH  - Omeprazole/*analogs & derivatives/metabolism/therapeutic use
MH  - *Polymorphism, Genetic
MH  - *Proton Pump Inhibitors
MH  - Proton-Translocating ATPases/antagonists & inhibitors
MH  - Rabeprazole
RF  - 40
EDAT- 2005/12/20 09:00
MHDA- 2006/04/28 09:00
CRDT- 2005/12/20 09:00
PHST- 2005/12/20 09:00 [pubmed]
PHST- 2006/04/28 09:00 [medline]
PHST- 2005/12/20 09:00 [entrez]
AID - JGH4167 [pii]
AID - 10.1111/j.1440-1746.2005.04167.x [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2005 Dec;20 Suppl:S22-8. doi: 
      10.1111/j.1440-1746.2005.04167.x.