PMID- 16359739
OWN - NLM
STAT- MEDLINE
DCOM- 20080116
LR  - 20140729
IS  - 0167-4943 (Print)
IS  - 0167-4943 (Linking)
VI  - 43
IP  - 2
DP  - 2006 Sep-Oct
TI  - Safety and low molecular weight heparin in older people in a hospital with 
      ambulatory care.
PG  - 233-41
AB  - To examine major bleeding and mortality rates of low molecular weight heparin 
      (LMWH) and unfractionated heparin (UFH) for patients with pulmonary embolism (PE) 
      and/or deep vein thrombosis (DVT), a retrospective review of the medical records 
      for 286 patients who presented at a local hospital with PE and/or DVT during the 
      period November 2002-August 2003 was performed. DATA COLLECTED: presence of 
      co-morbidities, concurrent medications, presence, site and severity of bleeding, 
      outcome. Of all the patients, 50.7% received LMWH plus warfarin, 21.0% received 
      UFH plus LMWH plus warfarin, 14.0% received UFH and warfarin, and 9.8% received 
      LMWH only. There were nine minor bleeds and six major bleeds, which resulted in 
      four deaths. Being a hospitalized patient and being age > or =70 years were 
      associated with a major bleed (p<0.05). For hospital inpatients age > or =70 
      years on UFH and LMWH the number of major bleeds/1000 patient days was 18.9 and 
      9.2, respectively. The major bleeding rate is comparable if not better than that 
      reported in the literature in our hospital setting where nearly half of the 
      anticoagulation services were provided as ambulatory care. The increased rate of 
      bleeding in the elderly we found is consistent with the findings of previous 
      studies.
FAU - Chan, Daniel K Y
AU  - Chan DK
AD  - Department of Aged Care & Rehabilitation, Bankstown-Lidcombe Hospital, University 
      of New South Wales, Locked Bag 1600, Bankstown, NSW 2200, Australia. 
      daniel.chan@swsahs.nsw.gov.au
FAU - Ong, Bin
AU  - Ong B
FAU - Almafragy, Hamid
AU  - Almafragy H
FAU - Karr, Margaret
AU  - Karr M
FAU - Hung, Arthur W T
AU  - Hung AW
FAU - Liu, Jun G
AU  - Liu JG
LA  - eng
PT  - Journal Article
DEP - 20051215
PL  - Netherlands
TA  - Arch Gerontol Geriatr
JT  - Archives of gerontology and geriatrics
JID - 8214379
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 5Q7ZVV76EI (Warfarin)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Aged
MH  - *Ambulatory Care
MH  - Anticoagulants/administration & dosage/*adverse effects
MH  - Blood Coagulation/*drug effects
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Female
MH  - Hemorrhage/*chemically induced/epidemiology
MH  - Heparin/adverse effects
MH  - Heparin, Low-Molecular-Weight/administration & dosage/*adverse effects
MH  - Hospitalization
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Medical Records
MH  - Middle Aged
MH  - New South Wales/epidemiology
MH  - Partial Thromboplastin Time
MH  - Pulmonary Embolism/*drug therapy/mortality
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Treatment Outcome
MH  - Venous Thrombosis/*drug therapy/mortality
MH  - Warfarin/therapeutic use
EDAT- 2005/12/20 09:00
MHDA- 2008/01/17 09:00
CRDT- 2005/12/20 09:00
PHST- 2004/06/07 00:00 [received]
PHST- 2005/10/20 00:00 [revised]
PHST- 2005/10/25 00:00 [accepted]
PHST- 2005/12/20 09:00 [pubmed]
PHST- 2008/01/17 09:00 [medline]
PHST- 2005/12/20 09:00 [entrez]
AID - S0167-4943(05)00142-1 [pii]
AID - 10.1016/j.archger.2005.10.011 [doi]
PST - ppublish
SO  - Arch Gerontol Geriatr. 2006 Sep-Oct;43(2):233-41. doi: 
      10.1016/j.archger.2005.10.011. Epub 2005 Dec 15.