PMID- 16359798
OWN - NLM
STAT- MEDLINE
DCOM- 20060330
LR  - 20210112
IS  - 0304-3959 (Print)
IS  - 0304-3959 (Linking)
VI  - 120
IP  - 1-2
DP  - 2006 Jan
TI  - Referred pain and hyperalgesia in human tendon and muscle belly tissue.
PG  - 113-123
LID - 10.1016/j.pain.2005.10.023 [doi]
AB  - The sensitivity of tendon and tendon-bone junction is not fully described 
      although these tissues have high clinical impacts. This study assessed (1) pain 
      intensity and referred pain caused by hypertonic saline injection to the proximal 
      tendon-bone junction (PTBJ), tendon and muscle belly sites of tibialis anterior 
      muscle and (2) pressure pain sensitivity, pre, during and post hypertonic saline 
      injections. Eighteen subjects (14 males and 4 females) participated. Subjects 
      also had constant mechanical stimulation for 120s at 130% of baseline pressure 
      pain threshold (PPT) during which VAS parameters were recorded. VAS parameters 
      after hypertonic saline for PTBJ (VAS area, VAS peak), and tendon sites (VAS 
      area, duration and time to maximum VAS) were significantly (P < 0.05) higher than 
      muscle belly. During hypertonic saline pain all three sites displayed local and 
      frequently enlarged and referred pain areas. Hypertonic saline pain at the PTBJ 
      and tendon transiently increased pressure sensitivity at these sites (P < 0.05). 
      When referred pain was caused by mechanical stimulation it occurred predominantly 
      at the PTBJ and tendon sites (86% cases). Constant mechanical stimulation caused 
      steadily increasing pain (summation of pain) at all sites. Hypertonic saline pain 
      at the tendon and PTBJ caused significantly higher (P < 0.001) final VAS scores 
      compared to the muscle belly site. The results indicate the PTBJ and tendon sites 
      are more sensitive and susceptible to sensitisation by hypertonic saline than 
      muscle belly. Furthermore, there may be site specific central changes reflected 
      by the differences in the results regarding sensitivity and summation over time.
FAU - Gibson, William
AU  - Gibson W
AD  - Laboratory for Experimental Pain Research, Center for Sensory-Motor Interaction 
      (SMI), Department of Health Science and Technology, Aalborg University, Fredrik 
      Bajers Vej 7D-3, DK-9220 Aalborg, Denmark.
FAU - Arendt-Nielsen, Lars
AU  - Arendt-Nielsen L
FAU - Graven-Nielsen, Thomas
AU  - Graven-Nielsen T
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051215
PL  - United States
TA  - Pain
JT  - Pain
JID - 7508686
RN  - 0 (Saline Solution, Hypertonic)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Hyperalgesia/chemically induced/diagnosis/*physiopathology
MH  - Injections, Intramuscular
MH  - Male
MH  - Muscles/drug effects/*physiopathology
MH  - Myofascial Pain Syndromes/chemically induced/diagnosis/*physiopathology
MH  - Pain Measurement/drug effects
MH  - Pain Threshold/drug effects
MH  - Saline Solution, Hypertonic/administration & dosage
MH  - Tendons/drug effects/*physiopathology
MH  - *Touch
EDAT- 2005/12/20 09:00
MHDA- 2006/03/31 09:00
CRDT- 2005/12/20 09:00
PHST- 2005/04/07 00:00 [received]
PHST- 2005/10/14 00:00 [revised]
PHST- 2005/10/24 00:00 [accepted]
PHST- 2005/12/20 09:00 [pubmed]
PHST- 2006/03/31 09:00 [medline]
PHST- 2005/12/20 09:00 [entrez]
AID - 00006396-200601000-00014 [pii]
AID - 10.1016/j.pain.2005.10.023 [doi]
PST - ppublish
SO  - Pain. 2006 Jan;120(1-2):113-123. doi: 10.1016/j.pain.2005.10.023. Epub 2005 Dec 
      15.