PMID- 16359995 OWN - NLM STAT- MEDLINE DCOM- 20060208 LR - 20181203 IS - 1556-5653 (Electronic) IS - 0015-0282 (Linking) VI - 84 IP - 6 DP - 2005 Dec TI - Effect of monocyte chemoattractant protein-1 and estradiol on the secretion of vascular endothelial growth factor in endometrial stromal cells in vitro. PG - 1793-6 AB - To explore the initial activity of endometrial stromal cells (ESCs) and the participation of monocyte chemoattractant protein-1 (MCP-1) in the histogenesis of endometriosis, vascular endothelial growth factor (VEGF) secretion of ESCs and the effect of MCP-1 on VEGF secretion of ESCs were observed in vitro. The VEGF level was detected in ESC culture media and was increased significantly when E2 or MCP-1 was added to the media, especially in the presence of E2 plus MCP-1. The VEGF secretion was higher in the ESCs of women with endometriosis than in those women without endometriosis. FAU - Lin, Jinfang AU - Lin J AD - Department of Gynecology, Obstetrics and Gynecology Hospital, Shanghai Medical College of Fudan University, Shanghai, China. FAU - Gu, Yu AU - Gu Y LA - eng PT - Journal Article PL - United States TA - Fertil Steril JT - Fertility and sterility JID - 0372772 RN - 0 (CCL2 protein, human) RN - 0 (Chemokine CCL2) RN - 0 (Vascular Endothelial Growth Factor A) RN - 4TI98Z838E (Estradiol) SB - IM MH - Adult MH - Cells, Cultured MH - Chemokine CCL2/*pharmacology MH - Drug Synergism MH - Endometriosis/etiology/*metabolism/pathology MH - Endometrium/*cytology MH - Estradiol/*pharmacology MH - Female MH - Humans MH - In Vitro Techniques MH - Stromal Cells/cytology/*drug effects/metabolism MH - Vascular Endothelial Growth Factor A/*metabolism EDAT- 2005/12/20 09:00 MHDA- 2006/02/09 09:00 CRDT- 2005/12/20 09:00 PHST- 2004/07/14 00:00 [received] PHST- 2005/03/28 00:00 [revised] PHST- 2005/03/28 00:00 [accepted] PHST- 2005/12/20 09:00 [pubmed] PHST- 2006/02/09 09:00 [medline] PHST- 2005/12/20 09:00 [entrez] AID - S0015-0282(05)03421-7 [pii] AID - 10.1016/j.fertnstert.2005.03.090 [doi] PST - ppublish SO - Fertil Steril. 2005 Dec;84(6):1793-6. doi: 10.1016/j.fertnstert.2005.03.090.