PMID- 16360051
OWN - NLM
STAT- MEDLINE
DCOM- 20060302
LR  - 20061115
IS  - 1558-3597 (Electronic)
IS  - 0735-1097 (Linking)
VI  - 46
IP  - 12
DP  - 2005 Dec 20
TI  - Electrical signals applied during the absolute refractory period: an 
      investigational treatment for advanced heart failure in patients with normal QRS 
      duration.
PG  - 2229-36
AB  - Cardiac resynchronization therapy has been shown to be an effective treatment for 
      patients with systolic ventricular dysfunction, prolonged (>120 ms) QRS duration, 
      and New York Heart Association (NYHA) functional class III or IV symptoms despite 
      optimal medical therapy. However, studies show that a majority of heart failure 
      patients have QRS duration <120 ms. We have been investigating the potential 
      utility of cardiac contractility modulating (CCM) signals as a treatment option 
      for such patients. Cardiac contractility modulating signals are non-excitatory 
      signals applied during the absolute refractory period using a pacemaker-like 
      device that connects to the heart with pacemaker leads. Acute studies carried out 
      in animals and humans with heart failure suggest that CCM signals can enhance the 
      strength of left ventricular contraction. Results of initial long-term studies 
      designed mainly to demonstrate feasibility and provide preliminary indication of 
      safety in patients with medically refractory NYHA functional class III heart 
      failure are summarized. The results of these preclinical and clinical studies 
      formed the basis for proceeding with two prospective, randomized clinical studies 
      currently underway to definitively test the safety and efficacy of this 
      treatment.
FAU - Lawo, Thomas
AU  - Lawo T
AD  - Berufgenossenschaftliche Kliniken Bergmannnsheil, Bochum, Germany.
FAU - Borggrefe, Martin
AU  - Borggrefe M
FAU - Butter, Christian
AU  - Butter C
FAU - Hindricks, Gerhard
AU  - Hindricks G
FAU - Schmidinger, Herwig
AU  - Schmidinger H
FAU - Mika, Yuval
AU  - Mika Y
FAU - Burkhoff, Daniel
AU  - Burkhoff D
FAU - Pappone, Carlo
AU  - Pappone C
FAU - Sabbah, Hani N
AU  - Sabbah HN
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
SB  - IM
MH  - Animals
MH  - Cardiac Output, Low/diagnosis/*physiopathology/*therapy
MH  - Cardiac Pacing, Artificial/*methods
MH  - *Electrocardiography
MH  - Humans
MH  - *Refractory Period, Electrophysiological
MH  - Severity of Illness Index
RF  - 50
EDAT- 2005/12/20 09:00
MHDA- 2006/03/03 09:00
CRDT- 2005/12/20 09:00
PHST- 2005/02/28 00:00 [received]
PHST- 2005/04/11 00:00 [revised]
PHST- 2005/05/10 00:00 [accepted]
PHST- 2005/12/20 09:00 [pubmed]
PHST- 2006/03/03 09:00 [medline]
PHST- 2005/12/20 09:00 [entrez]
AID - S0735-1097(05)02103-0 [pii]
AID - 10.1016/j.jacc.2005.05.093 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 2005 Dec 20;46(12):2229-36. doi: 10.1016/j.jacc.2005.05.093.