PMID- 16360134
OWN - NLM
STAT- MEDLINE
DCOM- 20060327
LR  - 20060123
IS  - 0008-8749 (Print)
IS  - 0008-8749 (Linking)
VI  - 237
IP  - 2
DP  - 2005 Oct
TI  - T cell priming by tissue-derived dendritic cells: new insights from recent murine 
      studies.
PG  - 77-85
AB  - Dendritic cells (DCs) act as sentinels in peripheral tissues, continuously 
      scavenging for antigens in their immediate surroundings. Their involvement in T 
      cell responses is generally thought to consist of a linear progression of events, 
      starting with capture of antigen in peripheral tissues such as the skin followed 
      by migration to draining lymphoid organs and MHC-restricted presentation of 
      antigen-derived peptide to induce T cell priming. The role of tissue-derived DCs 
      in the direct priming of immune responses has lately been challenged. It now 
      appears that, at least in some instances, a non-migratory subtype of DCs in the 
      secondary lymphoid tissue presents tissue-derived antigen to T cells. Here, we 
      review recent developments in research on DC function in the priming of immune 
      responses.
FAU - Sille, Fenna C M
AU  - Sille FC
AD  - Department of Dermatology, Brigham and Women's Hospital and Harvard Medical 
      School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
FAU - Visser, Annelies
AU  - Visser A
FAU - Boes, Marianne
AU  - Boes M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20051219
PL  - Netherlands
TA  - Cell Immunol
JT  - Cellular immunology
JID - 1246405
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Cell Movement
MH  - Dendritic Cells/classification/*immunology/physiology
MH  - Lymphocyte Activation
MH  - Lymphoid Tissue/cytology/immunology
MH  - Mice
MH  - Models, Immunological
MH  - Skin/cytology/immunology
MH  - T-Lymphocytes/*immunology
RF  - 129
EDAT- 2005/12/20 09:00
MHDA- 2006/03/28 09:00
CRDT- 2005/12/20 09:00
PHST- 2005/10/13 00:00 [received]
PHST- 2005/10/26 00:00 [accepted]
PHST- 2005/12/20 09:00 [pubmed]
PHST- 2006/03/28 09:00 [medline]
PHST- 2005/12/20 09:00 [entrez]
AID - S0008-8749(05)00240-6 [pii]
AID - 10.1016/j.cellimm.2005.10.004 [doi]
PST - ppublish
SO  - Cell Immunol. 2005 Oct;237(2):77-85. doi: 10.1016/j.cellimm.2005.10.004. Epub 
      2005 Dec 19.