PMID- 16360838
OWN - NLM
STAT- MEDLINE
DCOM- 20060510
LR  - 20051219
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 66
IP  - 9
DP  - 2005 Sep
TI  - Expansion of humoral donor-specific alloreactivity after renal transplantation 
      correlates with impaired graft outcome.
PG  - 985-8
AB  - IgG human leukocyte antigen (HLA) antibodies were investigated retrospectively 
      after transplantation in 264 primary renal graft recipients. All patients who 
      developed de novo donor-specific antibodies (DSA) and non-DSA (NDSA) (n = 40, 
      15.1%) were divided into two groups. Group A consisted of patients (n = 20) with 
      stable good graft function (GGF), and group B consisted of patients (n = 20) who 
      developed rejection and/or graft failure (R/GF). DSA were detected in 23 patients 
      (57.5%). Expansion of humoral alloreactivity with the presence of DSA to more 
      than one graft mismatched antigens and coexistence of HLA class I and II DSA were 
      significantly correlated only with R/GF (p = 0.01). Limitation of alloreactivity 
      to one graft-mismatched antigen was detected mainly in patients with GGF. HLA-DQ 
      DSA alone was found only in patients with GGF (p = 0.1). No significant 
      differences were found between the two patient groups with NDSA. Expansion of the 
      humoral alloreactivity to more than one graft molecule in renal transplant 
      recipients identifies patients at high risk of rejection or graft failure. 
      Limitation of humoral alloreactivity to one graft antigen perhaps associates the 
      presence of regulatory mechanisms with GGF only in specific cases.
FAU - Varnavidou-Nicolaidou, Agathi
AU  - Varnavidou-Nicolaidou A
AD  - Histocompatibility and Immunogenetics Laboratory, Paraskevaidion Surgical and 
      Transplant Center, Nicosia, Cyprus. avarnavidou@transplant.com.cy
FAU - Iniotaki-Theodoraki, Aliki G
AU  - Iniotaki-Theodoraki AG
FAU - Doxiadis, Ilias I N
AU  - Doxiadis II
FAU - Georgiou, Dora
AU  - Georgiou D
FAU - Patargias, Theocharis
AU  - Patargias T
FAU - Stavropoulos-Giokas, Catherine
AU  - Stavropoulos-Giokas C
FAU - Kyriakides, George
AU  - Kyriakides G
LA  - eng
PT  - Journal Article
DEP - 20050815
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-D Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - *Graft Rejection
MH  - HLA-D Antigens/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Isoantibodies/*blood
MH  - Kidney Transplantation/*immunology
MH  - Retrospective Studies
MH  - Tissue Donors
EDAT- 2005/12/20 09:00
MHDA- 2006/05/11 09:00
CRDT- 2005/12/20 09:00
PHST- 2005/03/17 00:00 [received]
PHST- 2005/07/08 00:00 [revised]
PHST- 2005/07/12 00:00 [accepted]
PHST- 2005/12/20 09:00 [pubmed]
PHST- 2006/05/11 09:00 [medline]
PHST- 2005/12/20 09:00 [entrez]
AID - S0198-8859(05)00127-8 [pii]
AID - 10.1016/j.humimm.2005.07.002 [doi]
PST - ppublish
SO  - Hum Immunol. 2005 Sep;66(9):985-8. doi: 10.1016/j.humimm.2005.07.002. Epub 2005 
      Aug 15.