PMID- 16360840
OWN - NLM
STAT- MEDLINE
DCOM- 20060510
LR  - 20181203
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 66
IP  - 9
DP  - 2005 Sep
TI  - TAP1 and TAP2 gene polymorphisms and HLA-TAP haplotypes in Koreans based on 90 
      families.
PG  - 998-1007
AB  - We have investigated the polymorphism of TAP genes and the distribution of human 
      leukocyte antigen (HLA)-TAP haplotypes in 90 Korean families (180 parents and 233 
      children), previously typed for HLA class II alleles. TAP1 (codons 333 and 637) 
      and TAP2 (codons 379, 565, 577, 651, 665, and 687) typings were carried out by 
      use of polymerase chain reaction-restriction fragment length polymorphism method. 
      For TAP1, four alleles (gene frequency: A 81.9%, B 15.0%, C 2.5%, D 0.5%) and for 
      TAP2, nine alleles (A1 31.7%, A2 14.2%, B 32.5%, Bky2 6.1%, C 6.9%, D 2.5%, E 
      3.9%, G 0.8%, and H 1.4%) were detected. Sixteen different TAP1-TAP2 haplotypes 
      were observed with frequencies > 0.5%, and we found that significant linkage 
      disequilibrium was present between TAP1 and TAP2 loci (p < 0.001). When 
      HLA-DRB1-DQB1 haplotypes were extended to TAP1 and TAP2 loci, much 
      diversification of haplotypes was observed: 26 different DRB1-DQB1 haplotypes 
      (frequencies > 0.8%) formed 90 different extended haplotypes. Eight recombinant 
      haplotypes between DQB1 and DPB1 loci were observed, and most (seven of eight) of 
      the recombinations occurred between TAP2 and DPB1 loci. These results add more 
      evidence to the view that recombination hot spot is present within and around TAP 
      gene region.
FAU - Whang, Dong Hee
AU  - Whang DH
AD  - Department of Laboratory Medicine, Inje University College of Medicine, Seoul 
      Paik Hospital, Seoul, Korea.
FAU - Park, Hyejin
AU  - Park H
FAU - Roh, Eun Youn
AU  - Roh EY
FAU - Park, Myoung Hee
AU  - Park MH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050816
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 2)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 3)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (TAP1 protein, human)
RN  - 145892-13-3 (TAP2 protein, human)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 2
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 3
MH  - ATP-Binding Cassette Transporters/*genetics
MH  - Gene Frequency
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Korea/epidemiology
MH  - *Polymorphism, Genetic
MH  - Recombination, Genetic
EDAT- 2005/12/20 09:00
MHDA- 2006/05/11 09:00
CRDT- 2005/12/20 09:00
PHST- 2005/05/06 00:00 [received]
PHST- 2005/07/08 00:00 [revised]
PHST- 2005/07/12 00:00 [accepted]
PHST- 2005/12/20 09:00 [pubmed]
PHST- 2006/05/11 09:00 [medline]
PHST- 2005/12/20 09:00 [entrez]
AID - S0198-8859(05)00128-X [pii]
AID - 10.1016/j.humimm.2005.07.001 [doi]
PST - ppublish
SO  - Hum Immunol. 2005 Sep;66(9):998-1007. doi: 10.1016/j.humimm.2005.07.001. Epub 
      2005 Aug 16.