PMID- 16361716
OWN - NLM
STAT- MEDLINE
DCOM- 20060126
LR  - 20190827
IS  - 0385-2407 (Print)
IS  - 0385-2407 (Linking)
VI  - 32
IP  - 9
DP  - 2005 Sep
TI  - ITP as an initial manifestation of subacute cutaneous lupus erythematosus.
PG  - 727-30
AB  - Subacute cutaneous lupus erythematosus (SCLE) is an entity characterized by 
      widespread polycyclic lesions that heal without scarring. Skin lesions with 
      marked ultraviolet sensitivity are distributed in an annular and/or psoriasiform 
      configuration. Idiopathic thrombocytopenic purpura, which is an autoimmune 
      disease (ITP), is mediated by a destructive immunoglobulin G antibody response to 
      the platelets' membrane components. We report a case of subacute cutaneous lupus 
      erythematosus initially manifested as thrombocytopenia, which was diagnosed as 
      idiopathic thrombocytopenic purpura (ITP) and treated with splenectomy. Seven 
      months later, development of cutaneous involvement followed the diagnosis of ITP. 
      The clinical and histological features of the lesions were compatible with SCLE. 
      Serological evaluations showed a negative anti-nuclear antibody test and an 
      elevated anti-SSB/La antibody level. Symptoms for systemic involvement were 
      negative. Although the clinical features such as photosensitivity, discoid rash, 
      and thrombocytopenia were in favor of SLE, the patient did not fulfill the 
      criteria of the American Rheumatism Association (ARA) for SLE.
FAU - Unal, Idil
AU  - Unal I
AD  - Department of Dermatology, Ege University Medical Faculty, Bornova-Izmir, Turkey.
FAU - Ceylan, Can
AU  - Ceylan C
FAU - Ozdemir, Fezal
AU  - Ozdemir F
FAU - Turk, Bengu Gerceker
AU  - Turk BG
FAU - Kazandi, Ali Can
AU  - Kazandi AC
FAU - Kandiloglu, Gulsen
AU  - Kandiloglu G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - J Dermatol
JT  - The Journal of dermatology
JID - 7600545
RN  - 886U3H6UFF (Chloroquine)
SB  - IM
MH  - Adult
MH  - Biopsy, Needle
MH  - Chloroquine/therapeutic use
MH  - Diagnosis, Differential
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunohistochemistry
MH  - Lupus Erythematosus, Cutaneous/diagnosis/drug therapy/*pathology
MH  - Purpura, Thrombocytopenic, Idiopathic/diagnosis/*pathology
MH  - Severity of Illness Index
MH  - Treatment Outcome
EDAT- 2005/12/20 09:00
MHDA- 2006/01/27 09:00
CRDT- 2005/12/20 09:00
PHST- 2004/09/21 00:00 [received]
PHST- 2005/04/06 00:00 [accepted]
PHST- 2005/12/20 09:00 [pubmed]
PHST- 2006/01/27 09:00 [medline]
PHST- 2005/12/20 09:00 [entrez]
AID - 032090727 [pii]
AID - 10.1111/j.1346-8138.2005.tb00833.x [doi]
PST - ppublish
SO  - J Dermatol. 2005 Sep;32(9):727-30. doi: 10.1111/j.1346-8138.2005.tb00833.x.