PMID- 16361856
OWN - NLM
STAT- MEDLINE
DCOM- 20060323
LR  - 20060417
IS  - 0253-5068 (Print)
IS  - 0253-5068 (Linking)
VI  - 24
IP  - 1
DP  - 2006
TI  - Oxidant and carbonyl stress-related apoptosis in end-stage kidney disease: impact 
      of membrane flux.
PG  - 149-56
AB  - Apoptosis is a highly regulated process which mostly affects cell-mediated 
      immunity. In this open-label, randomized, prospective clinical study, we 
      determined the impact in 10 hemodialysis patients treated with high-, medium-, 
      and low-flux membranes on spontaneous or plasma-induced apoptosis, on monocytes, 
      as well as on oxidant and carbonyl stress. High- and medium-flux membranes 
      significantly reduced patients' plasma-dependent proapoptotic activity on U937 
      monocytic cell lines. Patients who had the highest levels of plasma-induced 
      proapoptotic activity exhibited the highest plasma levels of advanced oxidation 
      protein products (AOPPs) and carbonyls. Plasma carbonyl residues but not AOPPs 
      were significantly lowered. Finally, a significant correlation could be drawn 
      between the extent of plasma-induced proapoptotic activity and both plasma 
      carbonyl and AOPP levels.
CI  - Copyright 2006 S. Karger AG, Basel.
FAU - Bordoni, Valeria
AU  - Bordoni V
AD  - Department of Nephrology, San Bortolo Hospital, Vicenza, Italy.
FAU - Piroddi, Marta
AU  - Piroddi M
FAU - Galli, Francesco
AU  - Galli F
FAU - de Cal, Massimo
AU  - de Cal M
FAU - Bonello, Monica
AU  - Bonello M
FAU - Dimitri, Petras
AU  - Dimitri P
FAU - Salvatori, Gabriella
AU  - Salvatori G
FAU - Ranishta, Rattanarat
AU  - Ranishta R
FAU - Levin, Nathan
AU  - Levin N
FAU - Tetta, Ciro
AU  - Tetta C
FAU - Ronco, Claudio
AU  - Ronco C
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Switzerland
TA  - Blood Purif
JT  - Blood purification
JID - 8402040
RN  - 0 (Blood Proteins)
RN  - 0 (Membranes, Artificial)
RN  - 0 (Oxidants)
SB  - IM
MH  - Adult
MH  - *Apoptosis
MH  - Blood Proteins/analysis
MH  - Female
MH  - Humans
MH  - Kidney Failure, Chronic/blood/*therapy
MH  - Male
MH  - *Membranes, Artificial
MH  - Middle Aged
MH  - *Monocytes
MH  - Oxidants/blood
MH  - Oxidation-Reduction
MH  - *Renal Dialysis
MH  - U937 Cells
EDAT- 2005/12/20 09:00
MHDA- 2006/03/24 09:00
CRDT- 2005/12/20 09:00
PHST- 2005/12/20 09:00 [pubmed]
PHST- 2006/03/24 09:00 [medline]
PHST- 2005/12/20 09:00 [entrez]
AID - 89452 [pii]
AID - 10.1159/000089452 [doi]
PST - ppublish
SO  - Blood Purif. 2006;24(1):149-56. doi: 10.1159/000089452.