PMID- 16362290
OWN - NLM
STAT- MEDLINE
DCOM- 20070430
LR  - 20160512
IS  - 1618-2642 (Print)
IS  - 1618-2642 (Linking)
VI  - 384
IP  - 3
DP  - 2006 Feb
TI  - Simultaneous optimization of resolution and analysis time in mixed micellar 
      liquid chromatography of coumarins by use of a utility function.
PG  - 851-8
AB  - A chemometrics approach has been used to optimize the separation of eight 
      coumarin compounds by mixed micellar liquid chromatography. A utility function, a 
      multi-criterion decision-making (MCDM) method, was tested for evaluation of two 
      different measures of chromatographic performance (resolution and analysis time). 
      The effect of six experimental parameters on a chromatographic response function 
      (CRF) was investigated. The factors studied were the concentrations of SDS and 
      Brij-35, alkyl-chain length of the alcohol used as organic modifier, organic 
      modifier concentration, mobile phase pH, and temperature. The experiments were 
      performed according to a face-centered cube response-surface experimental design. 
      For evaluation of the chromatograms a simple linear response function was used 
      which expressed as a summation of two optimization criteria, resolution and 
      analysis time. Then calculated CRF values were fitted to a polynomial model to 
      correlate the CRF values with the variables and their interactions. The 
      regression model obtained was characterized by both its descriptive and 
      predictive ability (R=0.963 and R2cv=0.861) and used, by means of a grid-search 
      algorithm, to optimize the chromatographic conditions. Experiments performed 
      under the optimum conditions predicted by the model produced a chromatogram of 
      high quality. The model was also verified by the good agreement observed between 
      predicted and experimental values of the chromatographic response function under 
      the optimum conditions.
FAU - Ebrahimi, P
AU  - Ebrahimi P
AD  - Department of Chemistry, University of Mazandaran, P.O. Box 453, Babolsar, Iran.
FAU - Hadjmohammadi, M R
AU  - Hadjmohammadi MR
LA  - eng
PT  - Journal Article
DEP - 20051217
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - 0 (Alcohols)
RN  - 0 (Coumarins)
RN  - 0 (Detergents)
RN  - 0 (Micelles)
SB  - IM
MH  - Alcohols/chemistry
MH  - Chromatography, High Pressure Liquid/methods
MH  - Coumarins/*analysis
MH  - Detergents/chemistry
MH  - Hydrogen-Ion Concentration
MH  - Micelles
MH  - Molecular Structure
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Temperature
MH  - Time Factors
EDAT- 2005/12/20 09:00
MHDA- 2007/05/01 09:00
CRDT- 2005/12/20 09:00
PHST- 2005/07/05 00:00 [received]
PHST- 2005/10/24 00:00 [accepted]
PHST- 2005/08/25 00:00 [revised]
PHST- 2005/12/20 09:00 [pubmed]
PHST- 2007/05/01 09:00 [medline]
PHST- 2005/12/20 09:00 [entrez]
AID - 10.1007/s00216-005-0216-1 [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2006 Feb;384(3):851-8. doi: 10.1007/s00216-005-0216-1. Epub 
      2005 Dec 17.