PMID- 16362307
OWN - NLM
STAT- MEDLINE
DCOM- 20061114
LR  - 20181113
IS  - 0174-1578 (Print)
IS  - 0174-1578 (Linking)
VI  - 176
IP  - 4
DP  - 2006 May
TI  - Direct influence of serotonin on the larval heart of Drosophila melanogaster.
PG  - 349-57
AB  - The heart rate (HR) of larval Drosophila is established to be modulated by 
      various neuromodulators. Serotonin (5-HT) showed dose-dependent responses in 
      direct application within semi-intact preparations. At 1 nM, HR decreased by 20% 
      while it increased at 10 nM (10%) and 100 nM (30%). The effects plateaued at 100 
      nM. The action of 5-HT on the heart was examined with an intact Central Nervous 
      System (CNS) and an ablated CNS. The heart and aorta of dorsal vessel pulsate at 
      different rates at rest and during exposure to 5-HT. Splitting the heart and 
      aorta resulted in a dramatic reduction in pulse rate of both the segments and the 
      addition of 5-HT did not produce regional differences. The split aorta and heart 
      showed a high degree of sensitivity to sham changes of saline but no significant 
      effect to 5-HT. Larvae-fed 5-HT (1 mM) did not show any significant change in HR. 
      Since 3,4-methylenedioxymethamphetamine (MDMA) is known to act as a weak agonist 
      on 5-HT receptors in vertebrates, we tested an exogenous application; however, no 
      significant effect was observed to dosage ranging from 1 nM to 100 microM in 
      larvae with and without an intact CNS. In summary, direct application of 5-HT to 
      the larval heart had significant effects in a dose-dependent manner while MDMA 
      had no effect.
FAU - Dasari, Sameera
AU  - Dasari S
AD  - Department of Biology, University of Kentucky, 675 Rose Street, Lexington, KY 
      40506-0225, USA.
FAU - Cooper, Robin L
AU  - Cooper RL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051214
PL  - Germany
TA  - J Comp Physiol B
JT  - Journal of comparative physiology. B, Biochemical, systemic, and environmental 
      physiology
JID - 8413200
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Aorta/drug effects/physiology
MH  - Central Nervous System/physiology
MH  - Dose-Response Relationship, Drug
MH  - Drosophila melanogaster/drug effects/*physiology
MH  - Heart Rate/*drug effects
MH  - In Vitro Techniques
MH  - Larva/physiology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Serotonin/*pharmacology
EDAT- 2005/12/20 09:00
MHDA- 2006/11/15 09:00
CRDT- 2005/12/20 09:00
PHST- 2005/11/07 00:00 [received]
PHST- 2005/11/23 00:00 [accepted]
PHST- 2005/11/16 00:00 [revised]
PHST- 2005/12/20 09:00 [pubmed]
PHST- 2006/11/15 09:00 [medline]
PHST- 2005/12/20 09:00 [entrez]
AID - 10.1007/s00360-005-0058-3 [doi]
PST - ppublish
SO  - J Comp Physiol B. 2006 May;176(4):349-57. doi: 10.1007/s00360-005-0058-3. Epub 
      2005 Dec 14.