PMID- 16364289
OWN - NLM
STAT- MEDLINE
DCOM- 20060321
LR  - 20220408
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 530
IP  - 1-2
DP  - 2006 Jan 13
TI  - Nitric oxide and its modulators in chronic constriction injury-induced 
      neuropathic pain in rats.
PG  - 59-69
AB  - This study was conducted to examine the role of nitric oxide (NO) in peripheral 
      neuropathy induced by chronic constriction injury of sciatic nerve of rats by 
      using NO precursor, NO donors and nitric oxide synthase (NOS) inhibitors. Chronic 
      constriction injury of sciatic nerve of rats resulted in peripheral neuropathy as 
      confirmed by nociceptive behavioural tests using mechanical, thermal and cold 
      allodynia. NO precursor, L-arginine and NO donors sodium nitroprusside, 
      S-nitroso-N-acetylpenicillamine potentiated the hyperalgesia and allodynia 
      significantly suggesting proalgesic effect in neuropathic rats. 
      Intracerebroventricular (i.c.v.) administration of rats with NOS inhibitors such 
      as L-N(G)-nitroarginine methyl ester, N-iminoethyl lysine and 7-nitroindazole did 
      not show any effect but i.p. administration of NOS inhibitors aminoguanidine, 
      L-N(G)-nitroarginine methyl ester and 7-nitroindazole caused alleviation of pain. 
      The study confirms the involvement of endogenously synthesized and exogenously 
      administered NO in chronic constriction injury-induced neuropathy in rats. 
      Significant increase in the levels of nitrate and nitrite in ligated sciatic 
      nerve suggest that local up regulation of NO in the production and maintenance of 
      neuropathic pain. In conclusion, initial attempt to manipulate L-arginine: NO 
      pathway is indicative of therapeutic potential of these interventions in the 
      management of neuropathic pain.
FAU - Naik, Ajit K
AU  - Naik AK
AD  - Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, 
      Izatnagar.
FAU - Tandan, Surendra K
AU  - Tandan SK
FAU - Kumar, Dinesh
AU  - Kumar D
FAU - Dudhgaonkar, Shailesh P
AU  - Dudhgaonkar SP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20051220
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Nitrates)
RN  - 0 (Nitric Oxide Donors)
RN  - 0 (Nitrites)
RN  - 169D1260KM (Nitroprusside)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 79032-48-7 (S-Nitroso-N-Acetylpenicillamine)
RN  - 94ZLA3W45F (Arginine)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
SB  - IM
MH  - Animals
MH  - Arginine/pharmacology
MH  - Behavior, Animal/drug effects
MH  - Cold Temperature/adverse effects
MH  - Constriction, Pathologic/complications
MH  - Disease Models, Animal
MH  - Hindlimb/innervation
MH  - Hot Temperature/adverse effects
MH  - Hyperalgesia/etiology/physiopathology
MH  - Injections, Intraperitoneal
MH  - Injections, Intraventricular
MH  - Male
MH  - Neuralgia/etiology/*physiopathology
MH  - Nitrates/blood
MH  - Nitric Oxide/metabolism/*physiology
MH  - Nitric Oxide Donors/administration & dosage
MH  - Nitric Oxide Synthase/antagonists & inhibitors/metabolism
MH  - Nitrites/blood
MH  - Nitroprusside/administration & dosage
MH  - Pain Threshold/drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - S-Nitroso-N-Acetylpenicillamine/administration & dosage
MH  - Sciatic Nerve/injuries/physiopathology
MH  - Stress, Mechanical
EDAT- 2005/12/21 09:00
MHDA- 2006/03/22 09:00
CRDT- 2005/12/21 09:00
PHST- 2005/11/10 00:00 [received]
PHST- 2005/11/14 00:00 [accepted]
PHST- 2005/12/21 09:00 [pubmed]
PHST- 2006/03/22 09:00 [medline]
PHST- 2005/12/21 09:00 [entrez]
AID - S0014-2999(05)01216-1 [pii]
AID - 10.1016/j.ejphar.2005.11.029 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2006 Jan 13;530(1-2):59-69. doi: 10.1016/j.ejphar.2005.11.029. 
      Epub 2005 Dec 20.