PMID- 16364336
OWN - NLM
STAT- MEDLINE
DCOM- 20060406
LR  - 20191210
IS  - 0021-9673 (Print)
IS  - 0021-9673 (Linking)
VI  - 1104
IP  - 1-2
DP  - 2006 Feb 3
TI  - Development of analytical methods for multiresidue determination of quinolones in 
      pig muscle samples by liquid chromatography with ultraviolet detection, liquid 
      chromatography-mass spectrometry and liquid chromatography-tandem mass 
      spectrometry.
PG  - 132-9
AB  - This paper presents a comparison between liquid chromatography with ultraviolet 
      detection (LC-UV), liquid chromatography-mass spectrometry (LC-MS) and liquid 
      chromatography-tandem mass spectrometry (LC-MS/MS) methods developed for the 
      multiresidue determination of 8 quinolones, around their maximum residue levels 
      (MRLs) in pig muscle. The procedure involves common extraction of the quinolones 
      from the tissues by traditional extraction, a step for clean-up and 
      preconcentration of the analytes by solid-phase extraction (SPE) and a subsequent 
      liquid chromatographic analysis. The methods present satisfactory results of 
      linearity, precision and limits of quantification much lower than the MRLs 
      established by the European Union for quinolones in pig tissues.
FAU - Hermo, M P
AU  - Hermo MP
AD  - Department of Analytical Chemistry, University of Barcelona, Avda. Diagonal 647, 
      E-08028 Barcelona, Spain.
FAU - Barron, D
AU  - Barron D
FAU - Barbosa, J
AU  - Barbosa J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20051220
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Quinolones)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*analysis
MH  - Calibration
MH  - Chromatography, Liquid/*methods
MH  - Drug Residues/*analysis
MH  - Mass Spectrometry/*methods
MH  - Muscles/*chemistry
MH  - Quinolones/*analysis
MH  - Reference Standards
MH  - Sensitivity and Specificity
MH  - Spectrophotometry, Ultraviolet/*methods
MH  - Swine
EDAT- 2005/12/21 09:00
MHDA- 2006/04/07 09:00
CRDT- 2005/12/21 09:00
PHST- 2005/09/14 00:00 [received]
PHST- 2005/11/18 00:00 [revised]
PHST- 2005/11/23 00:00 [accepted]
PHST- 2005/12/21 09:00 [pubmed]
PHST- 2006/04/07 09:00 [medline]
PHST- 2005/12/21 09:00 [entrez]
AID - S0021-9673(05)02266-1 [pii]
AID - 10.1016/j.chroma.2005.11.080 [doi]
PST - ppublish
SO  - J Chromatogr A. 2006 Feb 3;1104(1-2):132-9. doi: 10.1016/j.chroma.2005.11.080. 
      Epub 2005 Dec 20.