PMID- 16365741
OWN - NLM
STAT- MEDLINE
DCOM- 20060410
LR  - 20181113
IS  - 0093-7711 (Print)
IS  - 0093-7711 (Linking)
VI  - 57
IP  - 12
DP  - 2006 Jan
TI  - HLA class I and class II frequencies in patients with cutaneous malignant 
      melanoma from southeastern Spain: the role of HLA-C in disease prognosis.
PG  - 926-33
AB  - Available data have led to a controversy on the relationship between human 
      leukocyte antigen (HLA) and cutaneous malignant melanoma susceptibility or 
      prognosis. Moreover, the influence of HLA-C on melanoma has not yet been well 
      established. Therefore, the aim of the current study was to analyze the possible 
      influence of the HLA system on melanoma susceptibility and prognosis in the 
      Spanish population. For this purpose, HLA-A and HLA-B serotyping and HLA-C, 
      HLA-DRB1, and HLA-DQB1 genotyping by polymerase chain reactions using 
      sequence-specific oligonucleotide (PCR-SSO) and sequence-specific primer 
      (PCR-SSP) were performed in 174 melanoma patients and 227 ethnically matched 
      controls. The number of controls was increased up to 356 for HLA-C typing. 
      Patients were stratified according to the histological subtypes of melanoma, 
      sentinel lymph node status, tumor thickness, and ulceration of primary lesion. No 
      HLA-A, HLA-B, HLA-DRB1, or HLA-DQB1 relationship with melanoma was observed for 
      susceptibility or disease prognosis. However, the analysis of HLA-C locus showed 
      that individuals homozygous for HLA-C(Lys80) were significantly more frequent 
      within the patient than the control group. Remarkably, individuals homozygous for 
      group 2 HLA-C alleles (HLA-C(Lys80)) seem to be associated with metastatic 
      progression of melanoma. In contrast, we found a negative association between 
      group 1 HLA-C alleles (HLA-C(Asn80)) and disease susceptibility or metastasis 
      development. In conclusion, although an association with HLA-A, HLA-B, HLA-DRB1, 
      or HLA-DQB1 was not demonstrated, the study of the HLA-C locus revealed that the 
      analysis of the dimorphism at position 80 in the alpha1 helix may help to 
      evaluate the risk and prognosis of melanoma in our population.
FAU - Campillo, Jose A
AU  - Campillo JA
AD  - Immunology Service, Virgen de la Arrixaca University Hospital, Ctra. 
      Madrid-Cartagena, 30120, El Palmar, Murcia, Spain.
FAU - Martinez-Escribano, Jorge A
AU  - Martinez-Escribano JA
FAU - Muro, Manuel
AU  - Muro M
FAU - Moya-Quiles, Rosa
AU  - Moya-Quiles R
FAU - Marin, Luis A
AU  - Marin LA
FAU - Montes-Ares, Olga
AU  - Montes-Ares O
FAU - Guerra, Natalia
AU  - Guerra N
FAU - Sanchez-Pedreno, Paloma
AU  - Sanchez-Pedreno P
FAU - Frias, Jose F
AU  - Frias JF
FAU - Lozano, Jose A
AU  - Lozano JA
FAU - Garcia-Alonso, Ana M
AU  - Garcia-Alonso AM
FAU - Alvarez-Lopez, M Rocio
AU  - Alvarez-Lopez MR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051220
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - *Genes, MHC Class I
MH  - *Genes, MHC Class II
MH  - HLA-C Antigens/*genetics
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Male
MH  - Melanoma/*genetics/*immunology/secondary
MH  - Phenotype
MH  - Prognosis
MH  - Skin Neoplasms/*genetics/*immunology
MH  - Spain
EDAT- 2005/12/21 09:00
MHDA- 2006/04/11 09:00
CRDT- 2005/12/21 09:00
PHST- 2005/08/10 00:00 [received]
PHST- 2005/11/13 00:00 [accepted]
PHST- 2005/12/21 09:00 [pubmed]
PHST- 2006/04/11 09:00 [medline]
PHST- 2005/12/21 09:00 [entrez]
AID - 10.1007/s00251-005-0065-2 [doi]
PST - ppublish
SO  - Immunogenetics. 2006 Jan;57(12):926-33. doi: 10.1007/s00251-005-0065-2. Epub 2005 
      Dec 20.